A planned prospective, randomized, placebo-controlled multicenter trial assessing the effect of helicobacter pylori eradication on the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm

Sang Gyun Kim, Ho June Song, Il Ju Choi, Joo Young Cho, Hwoon Yong Jung, Bora Keum, Jae Hee Cheon, Yong Chan Lee, Jae Gyu Kim, Sue K. Park, Byung Joo Park, Hyun Chae Jung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/Aims: Helicobacter pylori eradication may facilitate the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm. This study involved designing a randomized, double-blinded, placebo- controlled, multicenter trial, performed by the Korean College of Helicobacter and Upper Gastrointestinal Research and the Medical Research Collaboration Center, Seoul National University Hospital. Methods: We intend to enroll up to 232 patients H.- pylori-positive patients who have gastric adenoma or early gastric cancer after endoscopic resection. The enrolled patients are being randomly allocated to the H.-pylori-eradication-plus-proton-pump-inhibitor group or the placebo-plus-proton-pump-inhibitor group based on their histology results and the size of the resected specimen. After random allocation, the iatrogenic ulcer size and stage are evaluated at 4- and 8-week follow- ups (with a window of ±7 days). The primary end point is the healing rate of the ulcer by stage, and the secondary end point is the rate of ulcer size reduction, relief rate from ulcer-related symptoms, and adverse-event rates. Results: More than 90% of the target subjects have already been enrolled into the study and are receiving ongoing periodic monitoring by the Medical Research Collaboration Center. Conclusions: Completion of the study should reveal whether H. pylori eradication can facilitate the healing of ulcer after endoscopic resection in Korea.

Original languageEnglish
Pages (from-to)514-517
Number of pages4
JournalGut and Liver
Volume4
Issue number4
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

Helicobacter pylori
Multicenter Studies
Ulcer
Stomach Neoplasms
Placebos
Proton Pump Inhibitors
Pylorus
Biomedical Research
Helicobacter
Korea
Random Allocation
Adenoma
Stomach
Histology
Research

Keywords

  • Endoscopic resection
  • Eradication
  • Helicobacter pylori
  • Iatrogenic ulcer
  • Medical research collaboration center

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

A planned prospective, randomized, placebo-controlled multicenter trial assessing the effect of helicobacter pylori eradication on the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm. / Kim, Sang Gyun; Song, Ho June; Choi, Il Ju; Cho, Joo Young; Jung, Hwoon Yong; Keum, Bora; Cheon, Jae Hee; Lee, Yong Chan; Kim, Jae Gyu; Park, Sue K.; Park, Byung Joo; Jung, Hyun Chae.

In: Gut and Liver, Vol. 4, No. 4, 01.12.2010, p. 514-517.

Research output: Contribution to journalArticle

Kim, Sang Gyun ; Song, Ho June ; Choi, Il Ju ; Cho, Joo Young ; Jung, Hwoon Yong ; Keum, Bora ; Cheon, Jae Hee ; Lee, Yong Chan ; Kim, Jae Gyu ; Park, Sue K. ; Park, Byung Joo ; Jung, Hyun Chae. / A planned prospective, randomized, placebo-controlled multicenter trial assessing the effect of helicobacter pylori eradication on the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm. In: Gut and Liver. 2010 ; Vol. 4, No. 4. pp. 514-517.
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