A possible 5'-NRIP1/UHRF1-3' fusion gene detected by array CGH analysis in a Ph+ ALL patient

Rui Zhang, Young Mi Kim, Xiaohe Yang, Yan Li, Shibo Li, Ji-Yun Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A translocation between chromosomes 19 and 21 [dic/t(19;21)(p13;v)] is very rare. To date, only three cases of this particular chromosomal abnormality have been reported. The translocations in these three cases were secondary changes in acute lymphoblastic leukemia (ALL) patients with the t(9;22) translocation. The gene(s) at the breakpoints of either chromosome 19p13 or 21q have not yet been identified. Here, we present a case study of a 21-year-old female with a diagnosis of precursor B cell ALL, with the t(9;22) translocation and secondary changes including a der(19)t(19;21) and an extra Philadelphia (Ph+) chromosome [der(22)t(9;22)]. Array comparative genomic hybridization (aCGH) analysis identified UHRF1 and NRIP1 as genes that were interrupted at the breakpoints of 19p13.3 and 21q21.1, and joined together as a possible fusion gene, 5'- NRIP1/UHRF1-3', on the derivative chromosome 19. To our knowledge, this is the first description of possible genes involved in the unbalanced translocation between chromosomes 19 and 21 in a patient with an ALL-positive for a t(9;22) translocation.

Original languageEnglish
Pages (from-to)687-691
Number of pages5
JournalCancer genetics
Volume204
Issue number12
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Chromosomes, Human, Pair 19
Gene Fusion
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Chromosomes, Human, Pair 21
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Chromosome Breakpoints
Genes
Chromosomes, Human, Pair 22
Philadelphia Chromosome
Comparative Genomic Hybridization
Chromosome Aberrations

Keywords

  • ALL
  • Array CGH
  • Fusion gene
  • NRIP1
  • UHRF1

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

A possible 5'-NRIP1/UHRF1-3' fusion gene detected by array CGH analysis in a Ph+ ALL patient. / Zhang, Rui; Kim, Young Mi; Yang, Xiaohe; Li, Yan; Li, Shibo; Lee, Ji-Yun.

In: Cancer genetics, Vol. 204, No. 12, 01.12.2011, p. 687-691.

Research output: Contribution to journalArticle

Zhang, Rui ; Kim, Young Mi ; Yang, Xiaohe ; Li, Yan ; Li, Shibo ; Lee, Ji-Yun. / A possible 5'-NRIP1/UHRF1-3' fusion gene detected by array CGH analysis in a Ph+ ALL patient. In: Cancer genetics. 2011 ; Vol. 204, No. 12. pp. 687-691.
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