A pressure-tolerant polymer microfluidic device fabricated by the simultaneous solidification-bonding method and flash chemistry application

Wurong Ren, Heejin Kim, Hyune Jea Lee, Jun Wang, Hao Wang, Dong Pyo Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Pressure-tolerant polymer-glass microfluidic reactors with excellent bonding strength have been fabricated by the simultaneous solidification-bonding (SSB) method, in which a viscous and reactive matrix polymer was cast on the glass substrate with pre-patterned wax as a sacrificial template. Elaborate interfacial chemistry between the matrix polymer and the functionalized glass surface was designed to achieve simultaneous solidification and chemical bonding under UV or/and mild thermal conditions (<200 °C with no pressure). Highly pressure-tolerant microchannels were obtained by complete removal of the liquid wax template at 80 °C. Versatility was demonstrated by fabricating microreactors from various polymers with different interfacial chemistry, which were all stable at 1000 psi with the highest burst pressure of 2000 psi. In particular, the fluoropolymer-glass microreactor can withstand a burst pressure that is two orders of magnitude higher than that of the microchannel made by the conventional method. Finally, the polymer-glass microfluidic device was used for the synthesis of a natural product, tryptanthrin, by flash chemistry under high pressure induced conditions (synthetic yield: 90%, flow rate: 10.5 mL min-1, reaction time: 14 ms). The transparent microfluidic device can be used as a useful platform for miniaturizing spectroscopic tools for chemical analysis studies under high pressure conditions.

Original languageEnglish
Pages (from-to)4263-4269
Number of pages7
JournalLab on a Chip
Volume14
Issue number21
DOIs
Publication statusPublished - 2014 Nov 7
Externally publishedYes

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Lab-On-A-Chip Devices
Microfluidics
Solidification
Polymers
Pressure
Glass
Waxes
Microchannels
Surface chemistry
Polymer matrix
Fluorine containing polymers
Biological Products
Hot Temperature

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

Cite this

A pressure-tolerant polymer microfluidic device fabricated by the simultaneous solidification-bonding method and flash chemistry application. / Ren, Wurong; Kim, Heejin; Lee, Hyune Jea; Wang, Jun; Wang, Hao; Kim, Dong Pyo.

In: Lab on a Chip, Vol. 14, No. 21, 07.11.2014, p. 4263-4269.

Research output: Contribution to journalArticle

Ren, Wurong ; Kim, Heejin ; Lee, Hyune Jea ; Wang, Jun ; Wang, Hao ; Kim, Dong Pyo. / A pressure-tolerant polymer microfluidic device fabricated by the simultaneous solidification-bonding method and flash chemistry application. In: Lab on a Chip. 2014 ; Vol. 14, No. 21. pp. 4263-4269.
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