A probable case of syndrome of inappropriate antidiuretic hormone secretion associated with linezolid

Seung Hee Baik, Yoon Kyung Choi, Hyun Seo Kim, Young Kyung Yoon, Jang Wook Sohn, Ja Kim Min

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4 Citations (Scopus)

Abstract

Purpose: A probable case of syndrome of inappropriate antidiuretic hormone secretion (SIADH) due to linezolid use is reported. Summary: An 81-year-old Korean woman hospitalized for progressive malignant otitis externa due to methicillin-resistant Staphylococcus aureus infection was started on linezolid therapy (600 mg i.v. twice daily). On day 22 of linezolid use, the patient had severe hyponatremia (serum sodium concentration, 118 meq/L), with stable vital signs and no specific physical findings except for somnolence. The patient's urine sodium concentration was 1183 meq/L, and her serum and urine osmolarity values were 250 and 357 mOsm/kg, respectively; these findings were consistent with SIADH. Hypertonic saline infusion and fluid restriction (

Original languageEnglish
Pages (from-to)1865-1869
Number of pages5
JournalAmerican Journal of Health-System Pharmacy
Volume72
Issue number21
DOIs
Publication statusPublished - 2015 Nov 1

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ASJC Scopus subject areas

  • Pharmacology
  • Health Policy

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