A probable case of syndrome of inappropriate antidiuretic hormone secretion associated with linezolid

Seung Hee Baik, Yoon Kyung Choi, Hyun Seo Kim, Young Kyung Yoon, Jang Wook Sohn, Ja Kim Min

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: A probable case of syndrome of inappropriate antidiuretic hormone secretion (SIADH) due to linezolid use is reported. Summary: An 81-year-old Korean woman hospitalized for progressive malignant otitis externa due to methicillin-resistant Staphylococcus aureus infection was started on linezolid therapy (600 mg i.v. twice daily). On day 22 of linezolid use, the patient had severe hyponatremia (serum sodium concentration, 118 meq/L), with stable vital signs and no specific physical findings except for somnolence. The patient's urine sodium concentration was 1183 meq/L, and her serum and urine osmolarity values were 250 and 357 mOsm/kg, respectively; these findings were consistent with SIADH. Hypertonic saline infusion and fluid restriction (

Original languageEnglish
Pages (from-to)1865-1869
Number of pages5
JournalAmerican Journal of Health-System Pharmacy
Volume72
Issue number21
DOIs
Publication statusPublished - 2015 Nov 1

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Linezolid
Inappropriate ADH Syndrome
Sodium
Urine
Otitis Externa
Hyponatremia
Vital Signs
Methicillin-Resistant Staphylococcus aureus
Serum
Osmolar Concentration
Infection

ASJC Scopus subject areas

  • Pharmacology
  • Health Policy

Cite this

A probable case of syndrome of inappropriate antidiuretic hormone secretion associated with linezolid. / Baik, Seung Hee; Choi, Yoon Kyung; Kim, Hyun Seo; Yoon, Young Kyung; Sohn, Jang Wook; Min, Ja Kim.

In: American Journal of Health-System Pharmacy, Vol. 72, No. 21, 01.11.2015, p. 1865-1869.

Research output: Contribution to journalArticle

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