A processed HLA-A*24:02 pseudogene found in the peripheral blood of a father and his son

S. Y. Ko, H. B. Oh, Y. H. Sohn, J. Jun, O. J. Kwon

Research output: Contribution to journalArticle

Abstract

We encountered a case that exhibited a discrepancy in human leukocyte antigen-A (HLA-A) type determined by sequence-based typing (SBT) and sequence-specific primer (SSP) molecular typing. The child of this case was identified as A*02:01 homozygote and A*02, A*24, respectively. The HLA-A type of his father was A*02:01, 26:01, but low-resolution SSP also showed unexpected amplification with A*24 primers as with the child. Serologic typing of the child and the father was A2/blank and A2/A26, respectively. Sequencing analysis of the A*24 variant in the child and the father showed a complete deletion of all introns of the A*24:02 allele. Though rare, this type of processed pseudogene variant can be one of the causes of discrepancies between high- and low-resolution HLA typing.

Original languageEnglish
Pages (from-to)244-246
Number of pages3
JournalTissue Antigens
Volume77
Issue number3
DOIs
Publication statusPublished - 2011 Mar

Keywords

  • HLA
  • Pseudogene
  • Sequence-based typing
  • Sequence-specific primer
  • Variant

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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