A prognostic scoring system using inflammatory response biomarkers in oral cavity squamous cell carcinoma patients who underwent surgery-based treatment

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The aim of this study was to evaluate the effectiveness of a scoring system based on the lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio for predicting disease-specific survival of oral cancer patients treated by surgery. Methods: From January 2007 to December 2016, we retrospectively analyzed data from 69 oral cancer patients who received surgery. Results: Lymphocyte-to-monocyte ratio was significantly associated with T classification, N classification, and pathologic stage. Neutrophil-to-lymphocyte ratio was significantly associated with T classification and pathologic stage. Platelet-to-lymphocyte ratio was significantly associated with N classification and pathologic stage. In multivariate analysis, only a higher score on this scoring system was significantly associated with poorer disease-specific survival. Conclusions: We found that the prognostic score system based on these three values was significantly associated with disease-specific survival of oral cancer patients who received surgery, indicating that the prognostic scoring system was effective in indirectly predicting systemic inflammatory response.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalActa Oto-Laryngologica
DOIs
Publication statusAccepted/In press - 2017 Nov 22

Fingerprint

Mouth
Squamous Cell Carcinoma
Biomarkers
Lymphocytes
Mouth Neoplasms
Survival
Monocytes
Neutrophils
Therapeutics
Blood Platelets
Multivariate Analysis

Keywords

  • Inflammatory response biomarker
  • oral cavity cancer
  • prognostic factor

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

@article{185203bedc7d45bc97c8741d0f25a31c,
title = "A prognostic scoring system using inflammatory response biomarkers in oral cavity squamous cell carcinoma patients who underwent surgery-based treatment",
abstract = "Background: The aim of this study was to evaluate the effectiveness of a scoring system based on the lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio for predicting disease-specific survival of oral cancer patients treated by surgery. Methods: From January 2007 to December 2016, we retrospectively analyzed data from 69 oral cancer patients who received surgery. Results: Lymphocyte-to-monocyte ratio was significantly associated with T classification, N classification, and pathologic stage. Neutrophil-to-lymphocyte ratio was significantly associated with T classification and pathologic stage. Platelet-to-lymphocyte ratio was significantly associated with N classification and pathologic stage. In multivariate analysis, only a higher score on this scoring system was significantly associated with poorer disease-specific survival. Conclusions: We found that the prognostic score system based on these three values was significantly associated with disease-specific survival of oral cancer patients who received surgery, indicating that the prognostic scoring system was effective in indirectly predicting systemic inflammatory response.",
keywords = "Inflammatory response biomarker, oral cavity cancer, prognostic factor",
author = "Park, {Young Min} and Oh, {Kyung Ho} and Jae-Gu Cho and Seung-Kuk Baek and Kwon, {Soon Young} and Kwang-Yoon Jung and Jeong-Soo Woo",
year = "2017",
month = "11",
day = "22",
doi = "10.1080/00016489.2017.1404640",
language = "English",
pages = "1--6",
journal = "Acta Oto-Laryngologica",
issn = "0001-6489",
publisher = "Informa Healthcare",

}

TY - JOUR

T1 - A prognostic scoring system using inflammatory response biomarkers in oral cavity squamous cell carcinoma patients who underwent surgery-based treatment

AU - Park, Young Min

AU - Oh, Kyung Ho

AU - Cho, Jae-Gu

AU - Baek, Seung-Kuk

AU - Kwon, Soon Young

AU - Jung, Kwang-Yoon

AU - Woo, Jeong-Soo

PY - 2017/11/22

Y1 - 2017/11/22

N2 - Background: The aim of this study was to evaluate the effectiveness of a scoring system based on the lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio for predicting disease-specific survival of oral cancer patients treated by surgery. Methods: From January 2007 to December 2016, we retrospectively analyzed data from 69 oral cancer patients who received surgery. Results: Lymphocyte-to-monocyte ratio was significantly associated with T classification, N classification, and pathologic stage. Neutrophil-to-lymphocyte ratio was significantly associated with T classification and pathologic stage. Platelet-to-lymphocyte ratio was significantly associated with N classification and pathologic stage. In multivariate analysis, only a higher score on this scoring system was significantly associated with poorer disease-specific survival. Conclusions: We found that the prognostic score system based on these three values was significantly associated with disease-specific survival of oral cancer patients who received surgery, indicating that the prognostic scoring system was effective in indirectly predicting systemic inflammatory response.

AB - Background: The aim of this study was to evaluate the effectiveness of a scoring system based on the lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio for predicting disease-specific survival of oral cancer patients treated by surgery. Methods: From January 2007 to December 2016, we retrospectively analyzed data from 69 oral cancer patients who received surgery. Results: Lymphocyte-to-monocyte ratio was significantly associated with T classification, N classification, and pathologic stage. Neutrophil-to-lymphocyte ratio was significantly associated with T classification and pathologic stage. Platelet-to-lymphocyte ratio was significantly associated with N classification and pathologic stage. In multivariate analysis, only a higher score on this scoring system was significantly associated with poorer disease-specific survival. Conclusions: We found that the prognostic score system based on these three values was significantly associated with disease-specific survival of oral cancer patients who received surgery, indicating that the prognostic scoring system was effective in indirectly predicting systemic inflammatory response.

KW - Inflammatory response biomarker

KW - oral cavity cancer

KW - prognostic factor

UR - http://www.scopus.com/inward/record.url?scp=85034748470&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034748470&partnerID=8YFLogxK

U2 - 10.1080/00016489.2017.1404640

DO - 10.1080/00016489.2017.1404640

M3 - Article

C2 - 29168424

AN - SCOPUS:85034748470

SP - 1

EP - 6

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

SN - 0001-6489

ER -