A prospective, multicenter analysis of pseudocapsule characteristics: Do all stages of renal cell carcinoma have complete pseudocapsules?

Seok Cho, Jeong Hyeon Lee, Seung Hyun Jeon, Jinsung Park, Sang Hyub Lee, Chul Hwan Kim, Ji Youn Sung, Joo Heon Kim, Jong Hyun Pyun, Jeong Gu Lee, Je-Jong Kim, Jun Cheon, Sung-Gu Kang, Seok Ho Kang

Research output: Contribution to journalArticle

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Abstract

Objectives To assess the characteristics of pseudocapsule (PC) in localized renal cell carcinoma (RCC) by analyzing the rates of completeness of PC and pseudocapsular invasion and clinical and pathological risk factors of it. Materials and methods Between February 2013 and September 2015, data were gathered prospectively from 180 consecutive patients who underwent partial nephrectomy or radical nephrectomy at 3 institutions, and 161 were enrolled. Evaluated factors included age and sex; histologic factors such as tumor diameter, stage, tumor subtype, necrosis, and Fuhrman grade; and clinical factors such as RENAL score; and completeness of PC. Results Only 94 tumors (58.4%) were surrounded by a continuous PC completely, 62 (38.5%) were partially surrounded, and 5 (3.1%) had no PC. Overall, 56 PCs (34.8%) were free from invasion, 58 PCs (36.0%) had partial invasion of PC without parenchymal invasion, and 47 PCs (29.2%) had parenchymal invasion. Defining parenchymal invasion as true pseudocapsular invasion, histologic diameter, RCC subtype, and completeness of PC were significant predictors for parenchymal invasion on multivariate analysis (P = 0.006, 0.046, and 0.002, respectively). Conclusions Rate of complete PC in RCC is relatively low in this study. The risk factors for pseudocapsular invasion were a histologic diameter greater than 4 cm, non–clear cell histology, and an incomplete PC. Surgeons must prepare for the possibility of a positive surgical margin if a tumor has at least one of these risk factors.

Original languageEnglish
Pages (from-to)370-378
Number of pages9
JournalUrologic Oncology: Seminars and Original Investigations
Volume35
Issue number6
DOIs
Publication statusPublished - 2017 Jun 1

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Renal Cell Carcinoma
Nephrectomy
Neoplasms
Sex Factors
Age Factors
Histology
Necrosis
Multivariate Analysis

Keywords

  • Kidney neoplasms
  • Partial nephrectomy
  • Pseudocapsule

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

A prospective, multicenter analysis of pseudocapsule characteristics : Do all stages of renal cell carcinoma have complete pseudocapsules? / Cho, Seok; Lee, Jeong Hyeon; Jeon, Seung Hyun; Park, Jinsung; Lee, Sang Hyub; Kim, Chul Hwan; Sung, Ji Youn; Kim, Joo Heon; Pyun, Jong Hyun; Lee, Jeong Gu; Kim, Je-Jong; Cheon, Jun; Kang, Sung-Gu; Kang, Seok Ho.

In: Urologic Oncology: Seminars and Original Investigations, Vol. 35, No. 6, 01.06.2017, p. 370-378.

Research output: Contribution to journalArticle

Cho, Seok ; Lee, Jeong Hyeon ; Jeon, Seung Hyun ; Park, Jinsung ; Lee, Sang Hyub ; Kim, Chul Hwan ; Sung, Ji Youn ; Kim, Joo Heon ; Pyun, Jong Hyun ; Lee, Jeong Gu ; Kim, Je-Jong ; Cheon, Jun ; Kang, Sung-Gu ; Kang, Seok Ho. / A prospective, multicenter analysis of pseudocapsule characteristics : Do all stages of renal cell carcinoma have complete pseudocapsules?. In: Urologic Oncology: Seminars and Original Investigations. 2017 ; Vol. 35, No. 6. pp. 370-378.
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abstract = "Objectives To assess the characteristics of pseudocapsule (PC) in localized renal cell carcinoma (RCC) by analyzing the rates of completeness of PC and pseudocapsular invasion and clinical and pathological risk factors of it. Materials and methods Between February 2013 and September 2015, data were gathered prospectively from 180 consecutive patients who underwent partial nephrectomy or radical nephrectomy at 3 institutions, and 161 were enrolled. Evaluated factors included age and sex; histologic factors such as tumor diameter, stage, tumor subtype, necrosis, and Fuhrman grade; and clinical factors such as RENAL score; and completeness of PC. Results Only 94 tumors (58.4{\%}) were surrounded by a continuous PC completely, 62 (38.5{\%}) were partially surrounded, and 5 (3.1{\%}) had no PC. Overall, 56 PCs (34.8{\%}) were free from invasion, 58 PCs (36.0{\%}) had partial invasion of PC without parenchymal invasion, and 47 PCs (29.2{\%}) had parenchymal invasion. Defining parenchymal invasion as true pseudocapsular invasion, histologic diameter, RCC subtype, and completeness of PC were significant predictors for parenchymal invasion on multivariate analysis (P = 0.006, 0.046, and 0.002, respectively). Conclusions Rate of complete PC in RCC is relatively low in this study. The risk factors for pseudocapsular invasion were a histologic diameter greater than 4 cm, non–clear cell histology, and an incomplete PC. Surgeons must prepare for the possibility of a positive surgical margin if a tumor has at least one of these risk factors.",
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author = "Seok Cho and Lee, {Jeong Hyeon} and Jeon, {Seung Hyun} and Jinsung Park and Lee, {Sang Hyub} and Kim, {Chul Hwan} and Sung, {Ji Youn} and Kim, {Joo Heon} and Pyun, {Jong Hyun} and Lee, {Jeong Gu} and Je-Jong Kim and Jun Cheon and Sung-Gu Kang and Kang, {Seok Ho}",
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T1 - A prospective, multicenter analysis of pseudocapsule characteristics

T2 - Do all stages of renal cell carcinoma have complete pseudocapsules?

AU - Cho, Seok

AU - Lee, Jeong Hyeon

AU - Jeon, Seung Hyun

AU - Park, Jinsung

AU - Lee, Sang Hyub

AU - Kim, Chul Hwan

AU - Sung, Ji Youn

AU - Kim, Joo Heon

AU - Pyun, Jong Hyun

AU - Lee, Jeong Gu

AU - Kim, Je-Jong

AU - Cheon, Jun

AU - Kang, Sung-Gu

AU - Kang, Seok Ho

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Objectives To assess the characteristics of pseudocapsule (PC) in localized renal cell carcinoma (RCC) by analyzing the rates of completeness of PC and pseudocapsular invasion and clinical and pathological risk factors of it. Materials and methods Between February 2013 and September 2015, data were gathered prospectively from 180 consecutive patients who underwent partial nephrectomy or radical nephrectomy at 3 institutions, and 161 were enrolled. Evaluated factors included age and sex; histologic factors such as tumor diameter, stage, tumor subtype, necrosis, and Fuhrman grade; and clinical factors such as RENAL score; and completeness of PC. Results Only 94 tumors (58.4%) were surrounded by a continuous PC completely, 62 (38.5%) were partially surrounded, and 5 (3.1%) had no PC. Overall, 56 PCs (34.8%) were free from invasion, 58 PCs (36.0%) had partial invasion of PC without parenchymal invasion, and 47 PCs (29.2%) had parenchymal invasion. Defining parenchymal invasion as true pseudocapsular invasion, histologic diameter, RCC subtype, and completeness of PC were significant predictors for parenchymal invasion on multivariate analysis (P = 0.006, 0.046, and 0.002, respectively). Conclusions Rate of complete PC in RCC is relatively low in this study. The risk factors for pseudocapsular invasion were a histologic diameter greater than 4 cm, non–clear cell histology, and an incomplete PC. Surgeons must prepare for the possibility of a positive surgical margin if a tumor has at least one of these risk factors.

AB - Objectives To assess the characteristics of pseudocapsule (PC) in localized renal cell carcinoma (RCC) by analyzing the rates of completeness of PC and pseudocapsular invasion and clinical and pathological risk factors of it. Materials and methods Between February 2013 and September 2015, data were gathered prospectively from 180 consecutive patients who underwent partial nephrectomy or radical nephrectomy at 3 institutions, and 161 were enrolled. Evaluated factors included age and sex; histologic factors such as tumor diameter, stage, tumor subtype, necrosis, and Fuhrman grade; and clinical factors such as RENAL score; and completeness of PC. Results Only 94 tumors (58.4%) were surrounded by a continuous PC completely, 62 (38.5%) were partially surrounded, and 5 (3.1%) had no PC. Overall, 56 PCs (34.8%) were free from invasion, 58 PCs (36.0%) had partial invasion of PC without parenchymal invasion, and 47 PCs (29.2%) had parenchymal invasion. Defining parenchymal invasion as true pseudocapsular invasion, histologic diameter, RCC subtype, and completeness of PC were significant predictors for parenchymal invasion on multivariate analysis (P = 0.006, 0.046, and 0.002, respectively). Conclusions Rate of complete PC in RCC is relatively low in this study. The risk factors for pseudocapsular invasion were a histologic diameter greater than 4 cm, non–clear cell histology, and an incomplete PC. Surgeons must prepare for the possibility of a positive surgical margin if a tumor has at least one of these risk factors.

KW - Kidney neoplasms

KW - Partial nephrectomy

KW - Pseudocapsule

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VL - 35

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JO - Urologic Oncology

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SN - 1078-1439

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