Abstract
Objectives To assess the characteristics of pseudocapsule (PC) in localized renal cell carcinoma (RCC) by analyzing the rates of completeness of PC and pseudocapsular invasion and clinical and pathological risk factors of it. Materials and methods Between February 2013 and September 2015, data were gathered prospectively from 180 consecutive patients who underwent partial nephrectomy or radical nephrectomy at 3 institutions, and 161 were enrolled. Evaluated factors included age and sex; histologic factors such as tumor diameter, stage, tumor subtype, necrosis, and Fuhrman grade; and clinical factors such as RENAL score; and completeness of PC. Results Only 94 tumors (58.4%) were surrounded by a continuous PC completely, 62 (38.5%) were partially surrounded, and 5 (3.1%) had no PC. Overall, 56 PCs (34.8%) were free from invasion, 58 PCs (36.0%) had partial invasion of PC without parenchymal invasion, and 47 PCs (29.2%) had parenchymal invasion. Defining parenchymal invasion as true pseudocapsular invasion, histologic diameter, RCC subtype, and completeness of PC were significant predictors for parenchymal invasion on multivariate analysis (P = 0.006, 0.046, and 0.002, respectively). Conclusions Rate of complete PC in RCC is relatively low in this study. The risk factors for pseudocapsular invasion were a histologic diameter greater than 4 cm, non–clear cell histology, and an incomplete PC. Surgeons must prepare for the possibility of a positive surgical margin if a tumor has at least one of these risk factors.
| Original language | English |
|---|---|
| Pages (from-to) | 370-378 |
| Number of pages | 9 |
| Journal | Urologic Oncology: Seminars and Original Investigations |
| Volume | 35 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2017 Jun 1 |
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Keywords
- Kidney neoplasms
- Partial nephrectomy
- Pseudocapsule
ASJC Scopus subject areas
- Oncology
- Urology
Cite this
A prospective, multicenter analysis of pseudocapsule characteristics : Do all stages of renal cell carcinoma have complete pseudocapsules? / Cho, Seok; Lee, Jeong Hyeon; Jeon, Seung Hyun; Park, Jinsung; Lee, Sang Hyub; Kim, Chul Hwan; Sung, Ji Youn; Kim, Joo Heon; Pyun, Jong Hyun; Lee, Jeong Gu; Kim, Je-Jong; Cheon, Jun; Kang, Sung-Gu; Kang, Seok Ho.
In: Urologic Oncology: Seminars and Original Investigations, Vol. 35, No. 6, 01.06.2017, p. 370-378.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A prospective, multicenter analysis of pseudocapsule characteristics
T2 - Do all stages of renal cell carcinoma have complete pseudocapsules?
AU - Cho, Seok
AU - Lee, Jeong Hyeon
AU - Jeon, Seung Hyun
AU - Park, Jinsung
AU - Lee, Sang Hyub
AU - Kim, Chul Hwan
AU - Sung, Ji Youn
AU - Kim, Joo Heon
AU - Pyun, Jong Hyun
AU - Lee, Jeong Gu
AU - Kim, Je-Jong
AU - Cheon, Jun
AU - Kang, Sung-Gu
AU - Kang, Seok Ho
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Objectives To assess the characteristics of pseudocapsule (PC) in localized renal cell carcinoma (RCC) by analyzing the rates of completeness of PC and pseudocapsular invasion and clinical and pathological risk factors of it. Materials and methods Between February 2013 and September 2015, data were gathered prospectively from 180 consecutive patients who underwent partial nephrectomy or radical nephrectomy at 3 institutions, and 161 were enrolled. Evaluated factors included age and sex; histologic factors such as tumor diameter, stage, tumor subtype, necrosis, and Fuhrman grade; and clinical factors such as RENAL score; and completeness of PC. Results Only 94 tumors (58.4%) were surrounded by a continuous PC completely, 62 (38.5%) were partially surrounded, and 5 (3.1%) had no PC. Overall, 56 PCs (34.8%) were free from invasion, 58 PCs (36.0%) had partial invasion of PC without parenchymal invasion, and 47 PCs (29.2%) had parenchymal invasion. Defining parenchymal invasion as true pseudocapsular invasion, histologic diameter, RCC subtype, and completeness of PC were significant predictors for parenchymal invasion on multivariate analysis (P = 0.006, 0.046, and 0.002, respectively). Conclusions Rate of complete PC in RCC is relatively low in this study. The risk factors for pseudocapsular invasion were a histologic diameter greater than 4 cm, non–clear cell histology, and an incomplete PC. Surgeons must prepare for the possibility of a positive surgical margin if a tumor has at least one of these risk factors.
AB - Objectives To assess the characteristics of pseudocapsule (PC) in localized renal cell carcinoma (RCC) by analyzing the rates of completeness of PC and pseudocapsular invasion and clinical and pathological risk factors of it. Materials and methods Between February 2013 and September 2015, data were gathered prospectively from 180 consecutive patients who underwent partial nephrectomy or radical nephrectomy at 3 institutions, and 161 were enrolled. Evaluated factors included age and sex; histologic factors such as tumor diameter, stage, tumor subtype, necrosis, and Fuhrman grade; and clinical factors such as RENAL score; and completeness of PC. Results Only 94 tumors (58.4%) were surrounded by a continuous PC completely, 62 (38.5%) were partially surrounded, and 5 (3.1%) had no PC. Overall, 56 PCs (34.8%) were free from invasion, 58 PCs (36.0%) had partial invasion of PC without parenchymal invasion, and 47 PCs (29.2%) had parenchymal invasion. Defining parenchymal invasion as true pseudocapsular invasion, histologic diameter, RCC subtype, and completeness of PC were significant predictors for parenchymal invasion on multivariate analysis (P = 0.006, 0.046, and 0.002, respectively). Conclusions Rate of complete PC in RCC is relatively low in this study. The risk factors for pseudocapsular invasion were a histologic diameter greater than 4 cm, non–clear cell histology, and an incomplete PC. Surgeons must prepare for the possibility of a positive surgical margin if a tumor has at least one of these risk factors.
KW - Kidney neoplasms
KW - Partial nephrectomy
KW - Pseudocapsule
UR - http://www.scopus.com/inward/record.url?scp=85011928368&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85011928368&partnerID=8YFLogxK
U2 - 10.1016/j.urolonc.2017.01.003
DO - 10.1016/j.urolonc.2017.01.003
M3 - Article
C2 - 28188091
AN - SCOPUS:85011928368
VL - 35
SP - 370
EP - 378
JO - Urologic Oncology
JF - Urologic Oncology
SN - 1078-1439
IS - 6
ER -