A Prospective, Randomized, 6-Month Comparison of the Coronary Vasomotor Response Associated With a Zotarolimus- Versus a Sirolimus-Eluting Stent. Differential Recovery of Coronary Endothelial Dysfunction

Jin Won Kim, Hong Seog Seo, Jae Hyoung Park, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Seung Woon Rha, Chang Gyu Park, Dong Joo Oh

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Objectives: We prospectively compared coronary endothelial dysfunction in patients with zotarolimus-eluting stent (ZES) versus sirolimus-eluting stent (SES) implantation at 6-month follow-up. Background: A ZES has been associated with uniform and rapid healing of the endothelium. Methods: Fifty patients were randomly treated with intravascular ultrasound-guided stenting with a single stent to the mid-segment of the left anterior descending artery (20 ZES, 20 SES, and 10 bare-metal stents), and endothelial function was estimated before and after intervention at 6-month follow-up by incremental acetylcholine (Ach) (10, 20, 50, and 100 μg/min) and nitrate (200 μg/min) infusions into the left coronary ostium. The vascular response was quantitatively measured in the 5-mm segments proximal and distal to the stent. Results: In the drug-eluting stent groups, more intense vasoconstriction to incremental doses of Ach was observed at 6-month follow-up compared with the responses before stenting. Endothelial function associated with the ZES was more preserved at 6-month follow-up compared with the SES. Vasoconstriction to Ach was more prominent in the distal segments than the proximal segments in both the ZES and SES groups. Endothelium-independent vasodilation to nitrate did not differ significantly among the study groups. Conclusions: Vasoconstriction in response to Ach in the peri-stent region was less pronounced in the ZES group than the SES group at 6-month follow-up, which suggests that endothelial function associated with ZES can be more preserved than the SES.

Original languageEnglish
Pages (from-to)1653-1659
Number of pages7
JournalJournal of the American College of Cardiology
Volume53
Issue number18
DOIs
Publication statusPublished - 2009 May 5

Keywords

  • BMS
  • DES
  • SES
  • ZES
  • acetylcholine
  • endothelial dysfunction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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