A prospective randomized study on the mobilization of CD34+ cells comparing continuous intravenous vs subcutaneous administration of rhG-CSF in normal donors

K. E. Lee, Y. C. Mun, S. H. Nam, J. M. Kwon, S. M. Lee, M. A. Lee, E. S. Yoo, J. Y. Ahn, J. H. Kim, C. M. Seong

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The efficacy of mobilizing peripheral blood progenitor cells (PBPC) with continuous intravenous (c.i.v.) administration of rhG-CSF was randomly compared to subcutaneous (s.c.) administration, in 15 normal donors in each arm of the study for 6 days. The percentage and absolute numbers of CD34+ cells in the c.i.v. and s.c. groups increased maximally at day 3 and 5, respectively, when compared with the steady-state (day 0) level. Peak CD34+ cell levels were achieved on day 3 in the c.i.v. group, with more rapid results than in the s.c. group (49.3/ μl vs 35.9/μl, P = 0.043). Plasma rhG-CSF levels declined progressively during mobilization in each group as the WBC increased. The serum level of rhG-CSF did not correlate with CD34+ cell counts in the peripheral blood. Toxicity profiles in the c.i.v. and s.c. groups were similar. Each regimen was effective in successfully mobilizing the target CD34 cell number.

Original languageEnglish
Pages (from-to)1027-1031
Number of pages5
JournalBone Marrow Transplantation
Volume36
Issue number12
DOIs
Publication statusPublished - 2005 Dec

Keywords

  • CD34 cells
  • Continuous IV rhG-CSF
  • Mobilization
  • Normal individuals

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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