A protecting group-free divergent synthesis of natural benzofurans via one-pot synthesis of 2-bromo-6-hydroxybenzofurans

Aneesh Sivaraman, Dipesh S. Harmalkar, Jiyoon Kang, Yongseok Choi, Kyeong Lee

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2-Bromo-6-hydroxybenzofurans are potentially versatile intermediates for the divergent synthesis of numerous benzofuran-based natural products and their analogues. Herein we report the first one-pot strategy for the efficient synthesis of 2-bromo-6-hydroxybenzofurans. The present protocol provides shorter routes for the synthesis of moracins M, N, O and P; gramniphenols F and G; and morunigrol C using a protecting group-free approach.

Original languageEnglish
Pages (from-to)2153-2161
Number of pages9
JournalOrganic and Biomolecular Chemistry
Issue number8
Publication statusPublished - 2019 Jan 1


ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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