A protecting group-free divergent synthesis of natural benzofurans via one-pot synthesis of 2-bromo-6-hydroxybenzofurans

Aneesh Sivaraman, Dipesh S. Harmalkar, Jiyoon Kang, Yongseok Choi, Kyeong Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

2-Bromo-6-hydroxybenzofurans are potentially versatile intermediates for the divergent synthesis of numerous benzofuran-based natural products and their analogues. Herein we report the first one-pot strategy for the efficient synthesis of 2-bromo-6-hydroxybenzofurans. The present protocol provides shorter routes for the synthesis of moracins M, N, O and P; gramniphenols F and G; and morunigrol C using a protecting group-free approach.

Original languageEnglish
Pages (from-to)2153-2161
Number of pages9
JournalOrganic and Biomolecular Chemistry
Volume17
Issue number8
DOIs
Publication statusPublished - 2019 Jan 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'A protecting group-free divergent synthesis of natural benzofurans via one-pot synthesis of 2-bromo-6-hydroxybenzofurans'. Together they form a unique fingerprint.

Cite this