A prototype CZT-based PET scanner for high resolution mouse brain imaging

P. Vaska, A. Dragone, Won Ho Lee, D. H. Kim, J. F. Pratte, Y. G. Cui, J. Fried, S. Krishnamoorthy, A. Bolotnikov, S. J. Park, P. O'Connor, F. A. Dilmanian, R. B. James

Research output: Chapter in Book/Report/Conference proceedingConference contribution

31 Citations (Scopus)

Abstract

One of the most challenging and potentially rewarding research applications of PET is imaging of the mouse brain. Although very high spatial resolution is required (< ∼ 1 mm), there is a much wider variety of transgenic models in mouse compared to the rat. The solid state material CdZnTe (CZT) has long held promise for high resolution PET. Compared to scintillators, its limitations in time resolution and sensitivity can in some ways be compensated by its extremely high spatial and energy resolution, its compact geometry, and by sophisticated data processing techniques. Using such techniques, a time resolution of ∼10 ns has been demonstrated for ∼1 cm thick CZT pixel detectors, and this may be sufficient for mouse studies. The depth-of-interaction capability and high energy resolution can improve sensitivity by allowing detectors to be placed very close to the subject and by enabling both reconstruction of detector-scattered events and rejection of object-scattered events. A full-ring prototype scanner has been designed to demonstrate feasibility of the concept, consisting of 6 CZT pixel detectors in a novel geometry. The design of the detector, front-end electronics components, and data acquisition are presented, along with performance characterization of the custom-manufactured CZT detectors.

Original languageEnglish
Title of host publication2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
Pages3816-3819
Number of pages4
Volume5
DOIs
Publication statusPublished - 2007
Externally publishedYes
Event2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC - Honolulu, HI, United States
Duration: 2007 Oct 272007 Nov 3

Other

Other2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
CountryUnited States
CityHonolulu, HI
Period07/10/2707/11/3

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ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Vaska, P., Dragone, A., Lee, W. H., Kim, D. H., Pratte, J. F., Cui, Y. G., Fried, J., Krishnamoorthy, S., Bolotnikov, A., Park, S. J., O'Connor, P., Dilmanian, F. A., & James, R. B. (2007). A prototype CZT-based PET scanner for high resolution mouse brain imaging. In 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC (Vol. 5, pp. 3816-3819). [4436952] https://doi.org/10.1109/NSSMIC.2007.4436952