Abstract
One of the most challenging and potentially rewarding research applications of PET is imaging of the mouse brain. Although very high spatial resolution is required (< ∼ 1 mm), there is a much wider variety of transgenic models in mouse compared to the rat. The solid state material CdZnTe (CZT) has long held promise for high resolution PET. Compared to scintillators, its limitations in time resolution and sensitivity can in some ways be compensated by its extremely high spatial and energy resolution, its compact geometry, and by sophisticated data processing techniques. Using such techniques, a time resolution of ∼10 ns has been demonstrated for ∼1 cm thick CZT pixel detectors, and this may be sufficient for mouse studies. The depth-of-interaction capability and high energy resolution can improve sensitivity by allowing detectors to be placed very close to the subject and by enabling both reconstruction of detector-scattered events and rejection of object-scattered events. A full-ring prototype scanner has been designed to demonstrate feasibility of the concept, consisting of 6 CZT pixel detectors in a novel geometry. The design of the detector, front-end electronics components, and data acquisition are presented, along with performance characterization of the custom-manufactured CZT detectors.
| Original language | English |
|---|---|
| Title of host publication | 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC |
| Pages | 3816-3819 |
| Number of pages | 4 |
| Volume | 5 |
| DOIs | |
| Publication status | Published - 2007 |
| Externally published | Yes |
| Event | 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC - Honolulu, HI, United States Duration: 2007 Oct 27 → 2007 Nov 3 |
Other
| Other | 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC |
|---|---|
| Country | United States |
| City | Honolulu, HI |
| Period | 07/10/27 → 07/11/3 |
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ASJC Scopus subject areas
- Radiation
- Nuclear and High Energy Physics
- Radiology Nuclear Medicine and imaging
Cite this
A prototype CZT-based PET scanner for high resolution mouse brain imaging. / Vaska, P.; Dragone, A.; Lee, Won Ho; Kim, D. H.; Pratte, J. F.; Cui, Y. G.; Fried, J.; Krishnamoorthy, S.; Bolotnikov, A.; Park, S. J.; O'Connor, P.; Dilmanian, F. A.; James, R. B.
2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC. Vol. 5 2007. p. 3816-3819 4436952.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - A prototype CZT-based PET scanner for high resolution mouse brain imaging
AU - Vaska, P.
AU - Dragone, A.
AU - Lee, Won Ho
AU - Kim, D. H.
AU - Pratte, J. F.
AU - Cui, Y. G.
AU - Fried, J.
AU - Krishnamoorthy, S.
AU - Bolotnikov, A.
AU - Park, S. J.
AU - O'Connor, P.
AU - Dilmanian, F. A.
AU - James, R. B.
PY - 2007
Y1 - 2007
N2 - One of the most challenging and potentially rewarding research applications of PET is imaging of the mouse brain. Although very high spatial resolution is required (< ∼ 1 mm), there is a much wider variety of transgenic models in mouse compared to the rat. The solid state material CdZnTe (CZT) has long held promise for high resolution PET. Compared to scintillators, its limitations in time resolution and sensitivity can in some ways be compensated by its extremely high spatial and energy resolution, its compact geometry, and by sophisticated data processing techniques. Using such techniques, a time resolution of ∼10 ns has been demonstrated for ∼1 cm thick CZT pixel detectors, and this may be sufficient for mouse studies. The depth-of-interaction capability and high energy resolution can improve sensitivity by allowing detectors to be placed very close to the subject and by enabling both reconstruction of detector-scattered events and rejection of object-scattered events. A full-ring prototype scanner has been designed to demonstrate feasibility of the concept, consisting of 6 CZT pixel detectors in a novel geometry. The design of the detector, front-end electronics components, and data acquisition are presented, along with performance characterization of the custom-manufactured CZT detectors.
AB - One of the most challenging and potentially rewarding research applications of PET is imaging of the mouse brain. Although very high spatial resolution is required (< ∼ 1 mm), there is a much wider variety of transgenic models in mouse compared to the rat. The solid state material CdZnTe (CZT) has long held promise for high resolution PET. Compared to scintillators, its limitations in time resolution and sensitivity can in some ways be compensated by its extremely high spatial and energy resolution, its compact geometry, and by sophisticated data processing techniques. Using such techniques, a time resolution of ∼10 ns has been demonstrated for ∼1 cm thick CZT pixel detectors, and this may be sufficient for mouse studies. The depth-of-interaction capability and high energy resolution can improve sensitivity by allowing detectors to be placed very close to the subject and by enabling both reconstruction of detector-scattered events and rejection of object-scattered events. A full-ring prototype scanner has been designed to demonstrate feasibility of the concept, consisting of 6 CZT pixel detectors in a novel geometry. The design of the detector, front-end electronics components, and data acquisition are presented, along with performance characterization of the custom-manufactured CZT detectors.
UR - http://www.scopus.com/inward/record.url?scp=48349137135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48349137135&partnerID=8YFLogxK
U2 - 10.1109/NSSMIC.2007.4436952
DO - 10.1109/NSSMIC.2007.4436952
M3 - Conference contribution
AN - SCOPUS:48349137135
SN - 1424409233
SN - 9781424409235
VL - 5
SP - 3816
EP - 3819
BT - 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
ER -