A randomized controlled trial of compression rates during cardiopulmonary resuscitation

Sung Oh Hwang, Kyoung Chul Cha, Kyuseok Kim, You Hwan Jo, Sung Phil Chung, Je Sung You, Jonghwan Shin, Hui Jai Lee, Yoo Seok Park, Seunghwan Kim, Sang Cheon Choi, Eun Jung Park, Won Young Kim, Dong Woo Seo, Sungwoo Moon, Gapsu Han, Han Sung Choi, Hyunggoo Kang, Seung Min Park, Woon Yong KwonEunhee Choi

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4 Citations (Scopus)

Abstract

The objective of this study was to compare the efficacy of cardiopulmonary resuscitation (CPR) with 120 compressions per minute (CPM) to CPR with 100 CPM in patients with non-traumatic out-of-hospital cardiac arrest. We randomly assigned patients with non-traumatic out-of-hospital cardiac arrest into two groups upon arrival to the emergency department (ED). The patients received manual CPR either with 100 CPM (CPR-100 group) or 120 CPM (CPR-120 group). The primary outcome measure was sustained restoration of spontaneous circulation (ROSC). The secondary outcome measures were survival discharge from the hospital, one-month survival, and one-month survival with good functional status. Of 470 patients with cardiac arrest, 136 patients in the CPR-100 group and 156 patients in the CPR-120 group were included in the final analysis. A total of 69 patients (50.7%) in the CPR-100 group and 67 patients (42.9%) in the CPR-120 group had ROSC (absolute difference, 7.8% points; 95% confidence interval [CI], -3.7 to 19.2%; P=0.183). The rates of survival discharge from the hospital, one-month survival, and one-month survival with good functional status were not different between the two groups (16.9% vs. 12.8%, P=0.325; 12.5% vs. 6.4%, P=0.073; 5.9% vs. 2.6%, P=0.154, respectively). We did not find differences in the resuscitation outcomes between those who received CPR with 100 CPM and those with 120 CPM. However, a large trial is warranted, with adequate power to confirm a statistically non-significant trend toward superiority of CPR with 100 CPM. (Clinical Trial Registration Information: www.cris.nih.go.kr, cris.nih.go.kr number, KCT0000231)

Original languageEnglish
Pages (from-to)1491-1498
Number of pages8
JournalJournal of Korean medical science
Volume31
Issue number9
DOIs
Publication statusPublished - 2016

Keywords

  • Basic life support
  • Cardiac arrest
  • Cardiopulmonary resuscitation

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Hwang, S. O., Cha, K. C., Kim, K., Jo, Y. H., Chung, S. P., You, J. S., Shin, J., Lee, H. J., Park, Y. S., Kim, S., Choi, S. C., Park, E. J., Kim, W. Y., Seo, D. W., Moon, S., Han, G., Choi, H. S., Kang, H., Park, S. M., ... Choi, E. (2016). A randomized controlled trial of compression rates during cardiopulmonary resuscitation. Journal of Korean medical science, 31(9), 1491-1498. https://doi.org/10.3346/jkms.2016.31.9.1491