A Randomized, Multi-Center, Clinical Trial to Assess the Efficacy and Safety of Alginate Carboxymethylcellulose Hyaluronic Acid Compared to Carboxymethylcellulose Hyaluronic Acid to Prevent Postoperative Intrauterine Adhesion

Tak Kim, Ki Hoon Ahn, Doo Seok Choi, Kyung Joo Hwang, Byoung Ick Lee, Min Hyung Jung, Jae Weon Kim, Jong Hyuk Kim, Sun Hee Cha, Ki Hwan Lee, Kyu Sup Lee, Sung Tack Oh, Chi Heum Cho, Jeong Ho Rhee

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Study Objective: To estimate the efficacy of alginate carboxymethylcellulose hyaluronic acid (ACH) gel to prevent intrauterine adhesions after hysteroscopic surgery in comparison with carboxymethylcellulose hyaluronic acid (CH) gel, which is known as an effective adhesion inhibitor. Design: Randomized, multicenter, single-blind, clinical trial (Canadian Task Force classification I). Setting: Tertiary university hospital. Patients: One hundred eighty-seven patients with a surgically treatable intrauterine lesion (myomas, polyps, septa, intrauterine adhesion, dysfunctional uterine bleeding). Interventions: Patients were randomized to 2 groups: hysteroscopic surgery plus intrauterine application of ACH or CH. Measurements and Results: The rate of adhesion formation and the adhesion severity score with type and extent were calculated 4 weeks after surgery. The ACH group had results that were comparable to the CH group in terms of the development of intrauterine adhesions at 4 weeks follow-up. The adhesion severities were not different between the 2 groups. In a subgroup without baseline intrauterine adhesion, the ACH group showed a lower intrauterine adhesion rate than the CH group (p = .016). Conclusions: ACH had a comparable efficacy to CH in terms of the adhesion rate and severity. In the case of no baseline intrauterine adhesion, intrauterine application of ACH after hysteroscopic surgery had a lower rate of intrauterine adhesion than application of CH.

Original languageEnglish
Pages (from-to)731-736
Number of pages6
JournalJournal of Minimally Invasive Gynecology
Volume19
Issue number6
DOIs
Publication statusPublished - 2012 Nov 1

Fingerprint

Carboxymethylcellulose Sodium
Hyaluronic Acid
Clinical Trials
Safety
Hysteroscopy
alginic acid
Gels
Myoma
Metrorrhagia
Advisory Committees
Polyps
Tertiary Care Centers

Keywords

  • Adhesion score
  • Alginate carboxymethylcellulose hyaluronic acid
  • Carboxymethylcellulose hyaluronic acid
  • Hysteroscopic surgery
  • Intrauterine adhesion

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

A Randomized, Multi-Center, Clinical Trial to Assess the Efficacy and Safety of Alginate Carboxymethylcellulose Hyaluronic Acid Compared to Carboxymethylcellulose Hyaluronic Acid to Prevent Postoperative Intrauterine Adhesion. / Kim, Tak; Ahn, Ki Hoon; Choi, Doo Seok; Hwang, Kyung Joo; Lee, Byoung Ick; Jung, Min Hyung; Kim, Jae Weon; Kim, Jong Hyuk; Cha, Sun Hee; Lee, Ki Hwan; Lee, Kyu Sup; Oh, Sung Tack; Cho, Chi Heum; Rhee, Jeong Ho.

In: Journal of Minimally Invasive Gynecology, Vol. 19, No. 6, 01.11.2012, p. 731-736.

Research output: Contribution to journalArticle

Kim, Tak ; Ahn, Ki Hoon ; Choi, Doo Seok ; Hwang, Kyung Joo ; Lee, Byoung Ick ; Jung, Min Hyung ; Kim, Jae Weon ; Kim, Jong Hyuk ; Cha, Sun Hee ; Lee, Ki Hwan ; Lee, Kyu Sup ; Oh, Sung Tack ; Cho, Chi Heum ; Rhee, Jeong Ho. / A Randomized, Multi-Center, Clinical Trial to Assess the Efficacy and Safety of Alginate Carboxymethylcellulose Hyaluronic Acid Compared to Carboxymethylcellulose Hyaluronic Acid to Prevent Postoperative Intrauterine Adhesion. In: Journal of Minimally Invasive Gynecology. 2012 ; Vol. 19, No. 6. pp. 731-736.
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abstract = "Study Objective: To estimate the efficacy of alginate carboxymethylcellulose hyaluronic acid (ACH) gel to prevent intrauterine adhesions after hysteroscopic surgery in comparison with carboxymethylcellulose hyaluronic acid (CH) gel, which is known as an effective adhesion inhibitor. Design: Randomized, multicenter, single-blind, clinical trial (Canadian Task Force classification I). Setting: Tertiary university hospital. Patients: One hundred eighty-seven patients with a surgically treatable intrauterine lesion (myomas, polyps, septa, intrauterine adhesion, dysfunctional uterine bleeding). Interventions: Patients were randomized to 2 groups: hysteroscopic surgery plus intrauterine application of ACH or CH. Measurements and Results: The rate of adhesion formation and the adhesion severity score with type and extent were calculated 4 weeks after surgery. The ACH group had results that were comparable to the CH group in terms of the development of intrauterine adhesions at 4 weeks follow-up. The adhesion severities were not different between the 2 groups. In a subgroup without baseline intrauterine adhesion, the ACH group showed a lower intrauterine adhesion rate than the CH group (p = .016). Conclusions: ACH had a comparable efficacy to CH in terms of the adhesion rate and severity. In the case of no baseline intrauterine adhesion, intrauterine application of ACH after hysteroscopic surgery had a lower rate of intrauterine adhesion than application of CH.",
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AU - Choi, Doo Seok

AU - Hwang, Kyung Joo

AU - Lee, Byoung Ick

AU - Jung, Min Hyung

AU - Kim, Jae Weon

AU - Kim, Jong Hyuk

AU - Cha, Sun Hee

AU - Lee, Ki Hwan

AU - Lee, Kyu Sup

AU - Oh, Sung Tack

AU - Cho, Chi Heum

AU - Rhee, Jeong Ho

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KW - Alginate carboxymethylcellulose hyaluronic acid

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