A randomized, prospective trial on efficacy and tolerability of low-volume bowel preparation methods for colonoscopy

In Kyung Yoo, Jong Soo Lee, Hoon-Jai Chun, Yoon Tae Jeen, Bora Keum, Eun-Sun Kim, Hyuk Soon Choi, Jae Min Lee, Seung Han Kim, Seung Joo Nam, Hyo Sung Kang, Hong Sik Lee, Chang Duck Kim, Soon-Ho Um, Yeon Seok Seo, Ho Sang Ryu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Low-volume bowel preparations have been shown to provide an equivalent cleansing effect as that of a standard 4 L polyethylene glycol. However, studies comparing the efficacy of low-volume bowel preparations are few, and the results have been controversial. This study aimed to compare the bowel cleansing quality and tolerability between sodium picosulfate/magnesium citrate and polyethylene glycol with ascorbic acid. Methods: A randomized study was performed with two hundred outpatients who were prospectively enrolled. The Boston Bowel Preparation Scale and the Aronchick scale were used to evaluate the bowel cleansing quality, and bubble scoring was also performed to back up both results. To investigate patients' preferences and tolerability, a questionnaire was administered. Results: Sodium picosulfate/magnesium citrate was not inferior to polyethylene glycol with ascorbic acid in terms of successful bowel preparation (≥6 Boston scale score: 80% vs. 82%; p = 0.718, adequate Aronchick grade: 93% vs. 96%; p = 0.352). In addition, sodium picosulfate/magnesium citrate caused fewer gastrointestinal symptoms, and tasted better than polyethylene glycol with ascorbic acid. Conclusions: Sodium picosulfate/magnesium citrate was not inferior to polyethylene glycol with ascorbic acid in cleansing efficacy, and was found to have higher tolerability.

Original languageEnglish
Pages (from-to)131-137
Number of pages7
JournalDigestive and Liver Disease
Volume47
Issue number2
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Colonoscopy
Ascorbic Acid
Patient Preference
Outpatients
magnesium citrate
picosulfate sodium

Keywords

  • Polyethylene glycol with ascorbic acid
  • Sodium picosulfate

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

@article{9034ee4898db4ba2a8c2393b28458951,
title = "A randomized, prospective trial on efficacy and tolerability of low-volume bowel preparation methods for colonoscopy",
abstract = "Background: Low-volume bowel preparations have been shown to provide an equivalent cleansing effect as that of a standard 4 L polyethylene glycol. However, studies comparing the efficacy of low-volume bowel preparations are few, and the results have been controversial. This study aimed to compare the bowel cleansing quality and tolerability between sodium picosulfate/magnesium citrate and polyethylene glycol with ascorbic acid. Methods: A randomized study was performed with two hundred outpatients who were prospectively enrolled. The Boston Bowel Preparation Scale and the Aronchick scale were used to evaluate the bowel cleansing quality, and bubble scoring was also performed to back up both results. To investigate patients' preferences and tolerability, a questionnaire was administered. Results: Sodium picosulfate/magnesium citrate was not inferior to polyethylene glycol with ascorbic acid in terms of successful bowel preparation (≥6 Boston scale score: 80{\%} vs. 82{\%}; p = 0.718, adequate Aronchick grade: 93{\%} vs. 96{\%}; p = 0.352). In addition, sodium picosulfate/magnesium citrate caused fewer gastrointestinal symptoms, and tasted better than polyethylene glycol with ascorbic acid. Conclusions: Sodium picosulfate/magnesium citrate was not inferior to polyethylene glycol with ascorbic acid in cleansing efficacy, and was found to have higher tolerability.",
keywords = "Polyethylene glycol with ascorbic acid, Sodium picosulfate",
author = "Yoo, {In Kyung} and Lee, {Jong Soo} and Hoon-Jai Chun and Jeen, {Yoon Tae} and Bora Keum and Eun-Sun Kim and Choi, {Hyuk Soon} and Lee, {Jae Min} and Kim, {Seung Han} and Nam, {Seung Joo} and Kang, {Hyo Sung} and Lee, {Hong Sik} and Kim, {Chang Duck} and Soon-Ho Um and Seo, {Yeon Seok} and Ryu, {Ho Sang}",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/j.dld.2014.10.019",
language = "English",
volume = "47",
pages = "131--137",
journal = "Digestive and Liver Disease",
issn = "1590-8658",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - A randomized, prospective trial on efficacy and tolerability of low-volume bowel preparation methods for colonoscopy

AU - Yoo, In Kyung

AU - Lee, Jong Soo

AU - Chun, Hoon-Jai

AU - Jeen, Yoon Tae

AU - Keum, Bora

AU - Kim, Eun-Sun

AU - Choi, Hyuk Soon

AU - Lee, Jae Min

AU - Kim, Seung Han

AU - Nam, Seung Joo

AU - Kang, Hyo Sung

AU - Lee, Hong Sik

AU - Kim, Chang Duck

AU - Um, Soon-Ho

AU - Seo, Yeon Seok

AU - Ryu, Ho Sang

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: Low-volume bowel preparations have been shown to provide an equivalent cleansing effect as that of a standard 4 L polyethylene glycol. However, studies comparing the efficacy of low-volume bowel preparations are few, and the results have been controversial. This study aimed to compare the bowel cleansing quality and tolerability between sodium picosulfate/magnesium citrate and polyethylene glycol with ascorbic acid. Methods: A randomized study was performed with two hundred outpatients who were prospectively enrolled. The Boston Bowel Preparation Scale and the Aronchick scale were used to evaluate the bowel cleansing quality, and bubble scoring was also performed to back up both results. To investigate patients' preferences and tolerability, a questionnaire was administered. Results: Sodium picosulfate/magnesium citrate was not inferior to polyethylene glycol with ascorbic acid in terms of successful bowel preparation (≥6 Boston scale score: 80% vs. 82%; p = 0.718, adequate Aronchick grade: 93% vs. 96%; p = 0.352). In addition, sodium picosulfate/magnesium citrate caused fewer gastrointestinal symptoms, and tasted better than polyethylene glycol with ascorbic acid. Conclusions: Sodium picosulfate/magnesium citrate was not inferior to polyethylene glycol with ascorbic acid in cleansing efficacy, and was found to have higher tolerability.

AB - Background: Low-volume bowel preparations have been shown to provide an equivalent cleansing effect as that of a standard 4 L polyethylene glycol. However, studies comparing the efficacy of low-volume bowel preparations are few, and the results have been controversial. This study aimed to compare the bowel cleansing quality and tolerability between sodium picosulfate/magnesium citrate and polyethylene glycol with ascorbic acid. Methods: A randomized study was performed with two hundred outpatients who were prospectively enrolled. The Boston Bowel Preparation Scale and the Aronchick scale were used to evaluate the bowel cleansing quality, and bubble scoring was also performed to back up both results. To investigate patients' preferences and tolerability, a questionnaire was administered. Results: Sodium picosulfate/magnesium citrate was not inferior to polyethylene glycol with ascorbic acid in terms of successful bowel preparation (≥6 Boston scale score: 80% vs. 82%; p = 0.718, adequate Aronchick grade: 93% vs. 96%; p = 0.352). In addition, sodium picosulfate/magnesium citrate caused fewer gastrointestinal symptoms, and tasted better than polyethylene glycol with ascorbic acid. Conclusions: Sodium picosulfate/magnesium citrate was not inferior to polyethylene glycol with ascorbic acid in cleansing efficacy, and was found to have higher tolerability.

KW - Polyethylene glycol with ascorbic acid

KW - Sodium picosulfate

UR - http://www.scopus.com/inward/record.url?scp=84921299922&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921299922&partnerID=8YFLogxK

U2 - 10.1016/j.dld.2014.10.019

DO - 10.1016/j.dld.2014.10.019

M3 - Article

C2 - 25464897

AN - SCOPUS:84921299922

VL - 47

SP - 131

EP - 137

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

SN - 1590-8658

IS - 2

ER -