A randomized, prospective trial on efficacy and tolerability of low-volume bowel preparation methods for colonoscopy

In Kyung Yoo, Jong Soo Lee, Hoon Jai Chun, Yoon Tae Jeen, Bora Keum, Eun Sun Kim, Hyuk Soon Choi, Jae Min Lee, Seung Han Kim, Seung Joo Nam, Hyo Sung Kang, Hong Sik Lee, Chang Duck Kim, Soon Ho Um, Yeon Seok Seo, Ho Sang Ryu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Low-volume bowel preparations have been shown to provide an equivalent cleansing effect as that of a standard 4 L polyethylene glycol. However, studies comparing the efficacy of low-volume bowel preparations are few, and the results have been controversial. This study aimed to compare the bowel cleansing quality and tolerability between sodium picosulfate/magnesium citrate and polyethylene glycol with ascorbic acid. Methods: A randomized study was performed with two hundred outpatients who were prospectively enrolled. The Boston Bowel Preparation Scale and the Aronchick scale were used to evaluate the bowel cleansing quality, and bubble scoring was also performed to back up both results. To investigate patients' preferences and tolerability, a questionnaire was administered. Results: Sodium picosulfate/magnesium citrate was not inferior to polyethylene glycol with ascorbic acid in terms of successful bowel preparation (≥6 Boston scale score: 80% vs. 82%; p = 0.718, adequate Aronchick grade: 93% vs. 96%; p = 0.352). In addition, sodium picosulfate/magnesium citrate caused fewer gastrointestinal symptoms, and tasted better than polyethylene glycol with ascorbic acid. Conclusions: Sodium picosulfate/magnesium citrate was not inferior to polyethylene glycol with ascorbic acid in cleansing efficacy, and was found to have higher tolerability.

Original languageEnglish
Pages (from-to)131-137
Number of pages7
JournalDigestive and Liver Disease
Volume47
Issue number2
DOIs
Publication statusPublished - 2015 Feb 1

Keywords

  • Polyethylene glycol with ascorbic acid
  • Sodium picosulfate

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Yoo, I. K., Lee, J. S., Chun, H. J., Jeen, Y. T., Keum, B., Kim, E. S., Choi, H. S., Lee, J. M., Kim, S. H., Nam, S. J., Kang, H. S., Lee, H. S., Kim, C. D., Um, S. H., Seo, Y. S., & Ryu, H. S. (2015). A randomized, prospective trial on efficacy and tolerability of low-volume bowel preparation methods for colonoscopy. Digestive and Liver Disease, 47(2), 131-137. https://doi.org/10.1016/j.dld.2014.10.019