A reflection-mode configuration for enhanced light delivery through turbidity

Timothy R. Hillman, Youngwoon Choi, Niyom Lue, Yongjin Sung, Ramachandra R. Dasari, Wonshik Choi, Zahid Yaqoob

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

We propose a method based on wavefront shaping for enhancing the backscattered light detected from any location in a sample medium, using low-coherence interferometry. The lateral phase profile of the light incident upon the sample is controlled using a spatial light modulator (SLM). In this manner, we apply an orthogonal set of phase masks to the illumination (input) and measure the backscattered signal response (output). These measurements permit us to determine the linear transformation between the input complex-amplitude modulation profile and the output time-resolved signal. Thus, we can determine the appropriate SLM write pattern for maximizing the detected signal for a given optical time delay (in the sample arm). In this manuscript, we are interested in the degree to which maximizing this signal also permits us to localize the three-dimensional sample region from which the backscattered signal is derived.

Original languageEnglish
Title of host publicationThree-Dimensional and Multidimensional Microscopy
Subtitle of host publicationImage Acquisition and Processing XIX
DOIs
Publication statusPublished - 2012
EventThree-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX - San Francisco, CA, United States
Duration: 2012 Jan 242012 Jan 26

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8227
ISSN (Print)1605-7422

Other

OtherThree-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX
CountryUnited States
CitySan Francisco, CA
Period12/1/2412/1/26

Keywords

  • Light scattering
  • deep tissue imaging
  • spatial light modulator
  • turbidity suppression

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Hillman, T. R., Choi, Y., Lue, N., Sung, Y., Dasari, R. R., Choi, W., & Yaqoob, Z. (2012). A reflection-mode configuration for enhanced light delivery through turbidity. In Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX [82271T] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8227). https://doi.org/10.1117/12.909735