TY - GEN
T1 - A reflection-mode configuration for enhanced light delivery through turbidity
AU - Hillman, Timothy R.
AU - Choi, Youngwoon
AU - Lue, Niyom
AU - Sung, Yongjin
AU - Dasari, Ramachandra R.
AU - Choi, Wonshik
AU - Yaqoob, Zahid
PY - 2012
Y1 - 2012
N2 - We propose a method based on wavefront shaping for enhancing the backscattered light detected from any location in a sample medium, using low-coherence interferometry. The lateral phase profile of the light incident upon the sample is controlled using a spatial light modulator (SLM). In this manner, we apply an orthogonal set of phase masks to the illumination (input) and measure the backscattered signal response (output). These measurements permit us to determine the linear transformation between the input complex-amplitude modulation profile and the output time-resolved signal. Thus, we can determine the appropriate SLM write pattern for maximizing the detected signal for a given optical time delay (in the sample arm). In this manuscript, we are interested in the degree to which maximizing this signal also permits us to localize the three-dimensional sample region from which the backscattered signal is derived.
AB - We propose a method based on wavefront shaping for enhancing the backscattered light detected from any location in a sample medium, using low-coherence interferometry. The lateral phase profile of the light incident upon the sample is controlled using a spatial light modulator (SLM). In this manner, we apply an orthogonal set of phase masks to the illumination (input) and measure the backscattered signal response (output). These measurements permit us to determine the linear transformation between the input complex-amplitude modulation profile and the output time-resolved signal. Thus, we can determine the appropriate SLM write pattern for maximizing the detected signal for a given optical time delay (in the sample arm). In this manuscript, we are interested in the degree to which maximizing this signal also permits us to localize the three-dimensional sample region from which the backscattered signal is derived.
KW - Light scattering
KW - deep tissue imaging
KW - spatial light modulator
KW - turbidity suppression
UR - http://www.scopus.com/inward/record.url?scp=84859592989&partnerID=8YFLogxK
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U2 - 10.1117/12.909735
DO - 10.1117/12.909735
M3 - Conference contribution
AN - SCOPUS:84859592989
SN - 9780819488701
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Three-Dimensional and Multidimensional Microscopy
T2 - Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX
Y2 - 24 January 2012 through 26 January 2012
ER -