A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon

David Jesse Sanchez, Daniel Miranda, Vaithilingaraja Arumugaswami, Seungmin Hwang, Adam E. Singer, Ashkon Senaati, Arash Shahangian, Moon Jung Song, Ren Sun, Genhong Cheng

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Abstract

Innate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce type I interferon, to date no natural DNA ligand of a virus that induces type I interferon has been described. Here we screened the genome of murine gammaherpesvirus 68 with mutations at various genomic locations to map the region of DNA that induces type I interferon. A repetitive region termed the 100-base-pair repeat region is a ligand that is both necessary and sufficient for the viral genomic DNA to induce type I interferon. A region colinear with this ligand in the genome of Kaposi's sarcoma-associated herpesvirus also induces type I interferon. We have thus defined a repetitive region of the genomes of gammaherpesviruses as the first natural DNA virus ligand that induces type I interferon.

Original languageEnglish
Pages (from-to)2208-2217
Number of pages10
JournalJournal of Virology
Volume82
Issue number5
DOIs
Publication statusPublished - 2008 Mar 1

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ASJC Scopus subject areas

  • Immunology

Cite this

Sanchez, D. J., Miranda, D., Arumugaswami, V., Hwang, S., Singer, A. E., Senaati, A., Shahangian, A., Song, M. J., Sun, R., & Cheng, G. (2008). A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon. Journal of Virology, 82(5), 2208-2217. https://doi.org/10.1128/JVI.01718-07