TY - JOUR
T1 - A review
T2 - flexible, stretchable multifunctional sensors and actuators for heart arrhythmia therapy
AU - Kang, Seung Jo
AU - Pak, James Jungho
N1 - Funding Information:
SJK and JJP wrote the manuscript. Both authors read and approved the final manuscript. Seung-Jo Kang received the B.S. degree in advanced materials science and engineering at Daejin University, Pocheon, Korea, in 2015. Currently, he is working toward the combined MS/PhD degree in the School of Electrical Engineering at Korea University, Seoul. His research interests include micro/nano-systems (MEMS/NEMS), electrochemical biosensors and energy harvesting using nano-structured materials. James Jungho Pak received B.S., M.S., and Ph.D. degrees in electrical engineering respectively in 1985, 1988, and 1992 at Purdue University. He had worked in Intel Corporation in Santa Clara, CA, USA from 1992 to 1995 as a senior device physic–cist. Since 1995, he has been a professor in the School of Electrical Engineering at Korea University. His research interests include the microsystems including bio-MEMS, biosensor, applications of polymer in micro-sensors and actuators, flexible electronics and novel semiconductor devices and processing. Not applicable The authors declare that they have no competing interests. The data and materials are available from the corresponding author of this paper. This work was supported by the R&D program of MOTIE/KEIT. [10054488, Development of cellular metabolic rate analyzer that can simultaneously measure multiple parameters (pH, dissolved oxygen, and metabolic heat) from less than 1000 cells]. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Publisher Copyright:
© 2017, The Author(s).
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Cardiovascular disease is a very serious disease which results in about 30% of all global mortality. Atrial fibrillation (AF) causes rapid and irregular contractions resulting in stroke and cardiac arrest. AF is caused by abnormality of the heartbeat controlling electrical signal. Catheter ablation (CA) is often used to treat and remove the abnormal electrical source from the heart but it has limitations in sensing capability and spatial coverage. To overcome the limitations of the CA, new devices for improving the spatial capability have been reported. One of the most impressive methods is wrapping the heart surface with a flexible/stretchable film with an array of high-density multifunctional micro-sensors and actuators. With this technique, the overall heart surface may be diagnosed in real time and the AF may be treated much more effectively. The data acquisition from the array of multifunctional sensors is also very important for making the new devices useful. To operate the implanted device system, a battery is mostly used and it should be avoided to replace the battery by surgery. Therefore, various energy harvesting techniques or wireless energy transfer techniques to continuously feed the power to the system are under investigation. The development of these technologies was reviewed, and the current level of technology was reviewed and summarized.
AB - Cardiovascular disease is a very serious disease which results in about 30% of all global mortality. Atrial fibrillation (AF) causes rapid and irregular contractions resulting in stroke and cardiac arrest. AF is caused by abnormality of the heartbeat controlling electrical signal. Catheter ablation (CA) is often used to treat and remove the abnormal electrical source from the heart but it has limitations in sensing capability and spatial coverage. To overcome the limitations of the CA, new devices for improving the spatial capability have been reported. One of the most impressive methods is wrapping the heart surface with a flexible/stretchable film with an array of high-density multifunctional micro-sensors and actuators. With this technique, the overall heart surface may be diagnosed in real time and the AF may be treated much more effectively. The data acquisition from the array of multifunctional sensors is also very important for making the new devices useful. To operate the implanted device system, a battery is mostly used and it should be avoided to replace the battery by surgery. Therefore, various energy harvesting techniques or wireless energy transfer techniques to continuously feed the power to the system are under investigation. The development of these technologies was reviewed, and the current level of technology was reviewed and summarized.
KW - 3D multifunctional integumentary membranes (3D-MIM)
KW - Atrial fibrillation (af)
KW - Balloon catheter
KW - Cardiac ablation (ca)
KW - Chronic implant device
KW - Implantable device
KW - Radiofrequency (RF) catheter
UR - http://www.scopus.com/inward/record.url?scp=85060702515&partnerID=8YFLogxK
U2 - 10.1186/s40486-017-0055-9
DO - 10.1186/s40486-017-0055-9
M3 - Review article
AN - SCOPUS:85060702515
VL - 5
JO - Micro and Nano Systems Letters
JF - Micro and Nano Systems Letters
SN - 2213-9621
IS - 1
M1 - 22
ER -