A review of low-intensity focused ultrasound pulsation

Alexander Bystritsky, Alex S. Korb, Pamela K. Douglas, Mark S. Cohen, William P. Melega, Amit P. Mulgaonkar, Antonio Desalles, Byoung-Kyong Min, Seung Schik Yoo

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

With the recent approval by the Food and Drug Administration (FDA) of Deep Brain Stimulation (DBS) for Parkinson's Disease, dystonia and obsessive compulsive disorder (OCD), vagus nerve stimulation (VNS) for epilepsy and depression, and repetitive transcranial magnetic stimulation (rTMS) for the treatment of depression, neuromodulation has become increasingly relevant to clinical research. However, these techniques have significant drawbacks (eg, lack of special specificity and depth for the rTMS, and invasiveness and cumbersome maintenance for DBS). This article reviews the background, rationale, and pilot studies to date, using a new brain stimulation method - low-intensity focused ultrasound pulsation (LIFUP). The ability of ultrasound to be focused noninvasively through the skull anywhere within the brain, together with concurrent imaging (ie, functional magnetic resonance imaging [fMRI]) techniques, may create a role for research and clinical use of LIFUP. This technique is still in preclinical testing and needs to be assessed thoroughly before being advanced to clinical trials. In this study, we review over 50 years of research data on the use of focused ultrasound (FUS) in neuronal tissue and live brain, and propose novel applications of this noninvasive neuromodulation method.

Original languageEnglish
Pages (from-to)125-136
Number of pages12
JournalBrain Stimulation
Volume4
Issue number3
DOIs
Publication statusPublished - 2011 Jul 1
Externally publishedYes

Fingerprint

Deep Brain Stimulation
Transcranial Magnetic Stimulation
Brain
Research
Depression
Vagus Nerve Stimulation
Aptitude
Dystonia
Obsessive-Compulsive Disorder
United States Food and Drug Administration
Skull
Parkinson Disease
Epilepsy
Maintenance
Magnetic Resonance Imaging
Clinical Trials
Therapeutics

Keywords

  • brain
  • neuroimaging
  • neuromodulation
  • treatment
  • ultrasound

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Biophysics

Cite this

Bystritsky, A., Korb, A. S., Douglas, P. K., Cohen, M. S., Melega, W. P., Mulgaonkar, A. P., ... Yoo, S. S. (2011). A review of low-intensity focused ultrasound pulsation. Brain Stimulation, 4(3), 125-136. https://doi.org/10.1016/j.brs.2011.03.007

A review of low-intensity focused ultrasound pulsation. / Bystritsky, Alexander; Korb, Alex S.; Douglas, Pamela K.; Cohen, Mark S.; Melega, William P.; Mulgaonkar, Amit P.; Desalles, Antonio; Min, Byoung-Kyong; Yoo, Seung Schik.

In: Brain Stimulation, Vol. 4, No. 3, 01.07.2011, p. 125-136.

Research output: Contribution to journalArticle

Bystritsky, A, Korb, AS, Douglas, PK, Cohen, MS, Melega, WP, Mulgaonkar, AP, Desalles, A, Min, B-K & Yoo, SS 2011, 'A review of low-intensity focused ultrasound pulsation', Brain Stimulation, vol. 4, no. 3, pp. 125-136. https://doi.org/10.1016/j.brs.2011.03.007
Bystritsky A, Korb AS, Douglas PK, Cohen MS, Melega WP, Mulgaonkar AP et al. A review of low-intensity focused ultrasound pulsation. Brain Stimulation. 2011 Jul 1;4(3):125-136. https://doi.org/10.1016/j.brs.2011.03.007
Bystritsky, Alexander ; Korb, Alex S. ; Douglas, Pamela K. ; Cohen, Mark S. ; Melega, William P. ; Mulgaonkar, Amit P. ; Desalles, Antonio ; Min, Byoung-Kyong ; Yoo, Seung Schik. / A review of low-intensity focused ultrasound pulsation. In: Brain Stimulation. 2011 ; Vol. 4, No. 3. pp. 125-136.
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