A robust, electrochemically driven microwell drug delivery system for controlled vasopressin release

Aram Chung, Yun Suk Huh, David Erickson

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Micro-electro-mechanical-system (MEMS) based implantable drug delivery devices represent a promising approach to achieving more precise dosing, faster release and better localization of therapeutic compounds than is possible with existing technology. Despite recent advancements, there remain challenges in being able to build systems that enable active control over the dose rate and release time, in a robust, low power but simple to fabricate package. Here we demonstrate an implantable microreservoir device that enables delivery of dose volumes as high as 15 μl using an electrochemically based transport mechanism. This approach allows for a significant reduction in the amount of time required for drug delivery as well as reducing the dependence on the external physiological conditions. We present the overall design, operating principle and construction of the device, and experimental results showing the volume transport rate as a function of the strength of the applied electric field. The concentration profile vs. time, the power consumption, and ejection efficiency are also investigated. To demonstrate the medical utility of the device we also characterize the in-vitro release of vasopressin.

Original languageEnglish
Pages (from-to)861-867
Number of pages7
JournalBiomedical Microdevices
Volume11
Issue number4
DOIs
Publication statusPublished - 2009 Apr 9
Externally publishedYes

Fingerprint

Drug Delivery Systems
Vasopressins
Drug delivery
Equipment and Supplies
Electric power utilization
Electric fields
Micro-Electrical-Mechanical Systems
Pharmaceutical Preparations
Technology
Therapeutics

Keywords

  • Drug delivery
  • Electrochemical reaction
  • Microfluidics
  • Microwell
  • Vasopressin

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

Cite this

A robust, electrochemically driven microwell drug delivery system for controlled vasopressin release. / Chung, Aram; Huh, Yun Suk; Erickson, David.

In: Biomedical Microdevices, Vol. 11, No. 4, 09.04.2009, p. 861-867.

Research output: Contribution to journalArticle

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