A safety assessment of phototoxicity and sensitization of SiO2 nanoparticles

Jae Eun Choi, Yoon Hee Park, Eun Young Lee, Sang Hoon Jeong, Sun Yae Kim, Meyoung Kon Kim, Sang Wook Son

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Despite widespread use of silicon dioxide (SiO2) NPs in industry and in our daily lives, no studies so far have evaluated the potential of their skin phototoxicity and sensitization. This study was designed to investigate the potential of phototoxicity and sensitization of SiO2 NPs. Assessment of the potential of skin phototoxicity was carried out using the 3T3 neutral red uptake test, an HSEM, and an animal model. The potential of skin sensitization was evaluated by a non-radioisotope local lymph node assay (non-RI LLNA). Findings from the present study suggest that the HSEM may be a reasonable model system for evaluation of skin phototoxicity of NPs. In addition, our data demonstrate that non-RI LLNA may be a useful method for identification of skin sensitization of NPs. In this study, we showed that SiO2 NPs do not induce phototoxicity or skin sensitization.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalMolecular and Cellular Toxicology
Volume7
Issue number2
DOIs
Publication statusPublished - 2011 Jun

Keywords

  • Human skin equivalent model
  • Phototoxicity
  • SiO nanoparticles
  • Skin sensitization

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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