A safety assessment of phototoxicity and sensitization of SiO2 nanoparticles

Jae Eun Choi; Yoon Hee Park; Eun Young Lee; Sang Hoon Jeong; Sun Yae Kim; Meyoung Kon Kim; Sang Wook Son

doi:10.1007/s13273-011-0023-z

A safety assessment of phototoxicity and sensitization of SiO₂ nanoparticles

Jae Eun Choi, Yoon Hee Park, Eun Young Lee, Sang Hoon Jeong, Sun Yae Kim, Meyoung Kon Kim, Sang Wook Son

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Despite widespread use of silicon dioxide (SiO₂) NPs in industry and in our daily lives, no studies so far have evaluated the potential of their skin phototoxicity and sensitization. This study was designed to investigate the potential of phototoxicity and sensitization of SiO₂ NPs. Assessment of the potential of skin phototoxicity was carried out using the 3T3 neutral red uptake test, an HSEM, and an animal model. The potential of skin sensitization was evaluated by a non-radioisotope local lymph node assay (non-RI LLNA). Findings from the present study suggest that the HSEM may be a reasonable model system for evaluation of skin phototoxicity of NPs. In addition, our data demonstrate that non-RI LLNA may be a useful method for identification of skin sensitization of NPs. In this study, we showed that SiO₂ NPs do not induce phototoxicity or skin sensitization.

Original language	English
Pages (from-to)	171-176
Number of pages	6
Journal	Molecular and Cellular Toxicology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1007/s13273-011-0023-z
Publication status	Published - 2011 Jun

Keywords

Human skin equivalent model
Phototoxicity
SiO nanoparticles
Skin sensitization

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Pharmacology, Toxicology and Pharmaceutics(all)
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s13273-011-0023-z

Cite this

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abstract = "Despite widespread use of silicon dioxide (SiO2) NPs in industry and in our daily lives, no studies so far have evaluated the potential of their skin phototoxicity and sensitization. This study was designed to investigate the potential of phototoxicity and sensitization of SiO2 NPs. Assessment of the potential of skin phototoxicity was carried out using the 3T3 neutral red uptake test, an HSEM, and an animal model. The potential of skin sensitization was evaluated by a non-radioisotope local lymph node assay (non-RI LLNA). Findings from the present study suggest that the HSEM may be a reasonable model system for evaluation of skin phototoxicity of NPs. In addition, our data demonstrate that non-RI LLNA may be a useful method for identification of skin sensitization of NPs. In this study, we showed that SiO2 NPs do not induce phototoxicity or skin sensitization.",

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AU - Choi, Jae Eun

AU - Park, Yoon Hee

AU - Lee, Eun Young

AU - Jeong, Sang Hoon

AU - Kim, Sun Yae

AU - Kim, Meyoung Kon

AU - Son, Sang Wook

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AB - Despite widespread use of silicon dioxide (SiO2) NPs in industry and in our daily lives, no studies so far have evaluated the potential of their skin phototoxicity and sensitization. This study was designed to investigate the potential of phototoxicity and sensitization of SiO2 NPs. Assessment of the potential of skin phototoxicity was carried out using the 3T3 neutral red uptake test, an HSEM, and an animal model. The potential of skin sensitization was evaluated by a non-radioisotope local lymph node assay (non-RI LLNA). Findings from the present study suggest that the HSEM may be a reasonable model system for evaluation of skin phototoxicity of NPs. In addition, our data demonstrate that non-RI LLNA may be a useful method for identification of skin sensitization of NPs. In this study, we showed that SiO2 NPs do not induce phototoxicity or skin sensitization.

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