A short PEG linker alters thein vivopharmacokinetics of trastuzumab to yield high-contrast immuno-PET images

Woonghee Lee, Kondapa Naidu Bobba, Jung Young Kim, Hyun Park, Abhinav Bhise, Wanook Kim, Kiwoong Lee, Subramani Rajkumar, Bora Nam, Kyo Chul Lee, Sang Hyuk Lee, Sanghwan Ko, Hye Jin Lee, Sang Taek Jung, Jeongsoo Yoo

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

The prolonged blood circulation of the radiolabeled antibody conjugates is problematic when using immuno-PET imaging due to the increased radiation exposure and longer hospitalization required until sufficient contrast develops. In contrast to the prevailing belief that PEGylation prolongs blood retention time, we observed that a PEGylated antibody with a short PEG8linker cleared much faster from the blood while maintaining tumor uptake compared to its non-PEGylated counterpart. Breast tumors were clearly visualized with a very high tumor-to-background ratio as early as 24 h after injection in immuno-positron emission tomography (PET) imaging.

Original languageEnglish
Pages (from-to)2993-2997
Number of pages5
JournalJournal of Materials Chemistry B
Volume9
Issue number13
DOIs
Publication statusPublished - 2021 Apr 7

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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