A Simple, Cleated DNA Walker That Hangs on to Surfaces

Cheulhee Jung, Peter B. Allen, Andrew D. Ellington

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

We designed and demonstrated a single-legged or unipedal walker that has a "cleat" that allows it to persistently associate with a track and make autonomous decisions about movement. The walker is highly processive over long periods of time, as shown by its movement over a microparticle surface suffused with substrate. The simple design can be readily optimized on the basis of simple energetic considerations. The walker can be used for signal amplification and should prove especially valuable for programming amorphous computations within chemical reaction networks.

Original languageEnglish
Pages (from-to)8047-8054
Number of pages8
JournalACS Nano
Volume11
Issue number8
DOIs
Publication statusPublished - 2017 Aug 22
Externally publishedYes

Keywords

  • catalytic hairpin assembly
  • DNA walker
  • microparticle
  • processive
  • proximity

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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