A Simple, Cleated DNA Walker That Hangs on to Surfaces

Cheulhee Jung; Peter B. Allen; Andrew D. Ellington

doi:10.1021/acsnano.7b02693

A Simple, Cleated DNA Walker That Hangs on to Surfaces

Cheulhee Jung, Peter B. Allen, Andrew D. Ellington

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Abstract

We designed and demonstrated a single-legged or unipedal walker that has a "cleat" that allows it to persistently associate with a track and make autonomous decisions about movement. The walker is highly processive over long periods of time, as shown by its movement over a microparticle surface suffused with substrate. The simple design can be readily optimized on the basis of simple energetic considerations. The walker can be used for signal amplification and should prove especially valuable for programming amorphous computations within chemical reaction networks.

Original language	English
Pages (from-to)	8047-8054
Number of pages	8
Journal	ACS nano
Volume	11
Issue number	8
DOIs	https://doi.org/10.1021/acsnano.7b02693
Publication status	Published - 2017 Aug 22
Externally published	Yes

Keywords

DNA walker
catalytic hairpin assembly
microparticle
processive
proximity

ASJC Scopus subject areas

Materials Science(all)
Engineering(all)
Physics and Astronomy(all)

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10.1021/acsnano.7b02693

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AU - Allen, Peter B.

AU - Ellington, Andrew D.

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KW - proximity

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A Simple, Cleated DNA Walker That Hangs on to Surfaces

Abstract

Keywords

ASJC Scopus subject areas

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