A single trial of transcutaneous electrical nerve stimulation reduces chronic neuropathic pain following median nerve injury in rats

Hwi Young Cho, Hye Rim Suh, Hee Chul Han

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Neuropathic pain is a devastating chronic condition and is often induced in the upper limb following nerve injury or damage. Various drugs or surgical methods have been used to manage neuropathic pain; however, these are frequently accompanied by undesirable side effects. Transcutaneous electrical nerve stimulation (TENS) is a safe and non-invasive intervention that has been used to alleviate different types of pain in the clinic, but it is unclear whether TENS can improve chronic neuropathic pain in the upper limb. Thus, the aim of this study was to investigate the effects of a single trial of TENS on chronic neuropathic pain following median nerve injury. Male rats weighing 200-250 g received median nerve-ligation of the right forearm, while the control group received only skin-incision without nerve-ligation. Neuropathic pain-behaviors, including mechanical, cold, and thermal allodynia, were measured for 4 weeks. After the development of chronic neuropathic pain, TENS (100 Hz, 200 μs, sub-motor threshold) or placebo-TENS (sham stimulation) was applied for 20 min to the ipsilateral or contralateral side. Neuropathic pain behavior was assessed before and after intervention. Median nerve-ligation significantly induced and maintained neuropathic pain in the ipsilateral side. TENS application to the ipsilateral side effectively attenuated the three forms of chronic neuropathic pain in the ipsilateral side compared to sham-treated rats (peripheral and central effects), while TENS application to contralateral side only reduced mechanical allodynia in the ipsilateral side (central effect). Our findings demonstrate that TENS can alleviate chronic neuropathic pain following median nerve injury.

Original languageEnglish
Pages (from-to)207-214
Number of pages8
JournalTohoku Journal of Experimental Medicine
Volume232
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Transcutaneous Electric Nerve Stimulation
Median Nerve
Neuralgia
Chronic Pain
Rats
Wounds and Injuries
Weighing
Skin
Hyperalgesia
Ligation
Pharmaceutical Preparations
Upper Extremity
Pain Clinics
Forearm
Placebos
Hot Temperature

Keywords

  • Carpal tunnel syndrome
  • Median nerve injury
  • Neuropathic pain
  • Rat
  • Transcutaneous electrical nerve stimulation

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

A single trial of transcutaneous electrical nerve stimulation reduces chronic neuropathic pain following median nerve injury in rats. / Cho, Hwi Young; Suh, Hye Rim; Han, Hee Chul.

In: Tohoku Journal of Experimental Medicine, Vol. 232, No. 3, 01.01.2014, p. 207-214.

Research output: Contribution to journalArticle

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