A smart biochip with hand-held analyzer for monitoring specific environmental biomarkers

Jungyoup Jay Han, Junhai Kai, Se Hwan Lee, Aniruddha Puntambekar, Ji Youn Lim, Dong Geun Sul, Chong H. Ahn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A new smart disposable biochip with a hand-held analyzer for monitoring specific environmental proteomic biomarkers has been designed, developed and fully characterized using polymer microfabrication technology and chemiluminescence immunoassay detection method. High sensitivity, small size, and low cost of the developed system are very suitable for exposure monitoring as a point-of-care (POC) platform. In this paper, Rho GDP inhibitor and triose phosphate isomerase as potential environmental biomarkers of di(2-ethylhexl) phthalate (DEHP) and human disease associate with DEHP were used for the developed biochip with the analyzer, demonstrating a POC platform. The smart biochip based analysis only requires <∼30 minutes, comparing to 4∼5 hours of a conventional ELISA.

Original languageEnglish
Title of host publicationTechnical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop
PublisherTransducer Research Foundation
Pages177-180
Number of pages4
ISBN (Print)9780964002494
Publication statusPublished - 2012
Event2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012 - Hilton Head, United States
Duration: 2012 Jun 32012 Jun 7

Other

Other2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012
CountryUnited States
CityHilton Head
Period12/6/312/6/7

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering
  • Hardware and Architecture

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  • Cite this

    Han, J. J., Kai, J., Lee, S. H., Puntambekar, A., Lim, J. Y., Sul, D. G., & Ahn, C. H. (2012). A smart biochip with hand-held analyzer for monitoring specific environmental biomarkers. In Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop (pp. 177-180). Transducer Research Foundation.