A study of RET proto-oncogene polymorphisms in association with lung cancer risk in the Korean population

Hyun Kyung Kim; Hae Yun Jung; Seungjoon Lim; Jae Sook Sung; Young Mi Whang; Ukhyun Jo; Jong Eun Lee; Sang Won Shin; Jun Suk Kim; Jeong Seon Ryu; Yeul Hong Kim

A study of RET proto-oncogene polymorphisms in association with lung cancer risk in the Korean population

Hyun Kyung Kim, Hae Yun Jung, Seungjoon Lim, Jae Sook Sung, Young Mi Whang, Ukhyun Jo, Jong Eun Lee, Sang Won Shin, Jun Suk Kim, Jeong Seon Ryu, Yeul Hong Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Background/Aim: This study examined whether the polymorphisms at the promoter region of RET gene are associated with the risk of lung cancer in the Korean population. Patients and Methods: A total of 409 Korean lung cancer patients and 409 normal subjects were recruited. PCR-RFLP, SNaP Shot assay and logistic regression analyses were performed to characterize the association between polymorphisms of RET and lung cancer risk. Results: Four SNPs (-1697 C>G, -1260 C>T, -719 C>T, -527 C>A) of RET were selected for large-scale genotyping. Statistical analyses revealed that novel -1260 C > T polymorphism and haplotype 3 (-1697G, -1260T, -719C, and -719C) were associated with the risk of lung cancer; specifically, there were significant associations within subgroups of males and smokers. Conclusion: These results demonstrated that this novel polymorphism of the RET gene is associated with an increased risk of lung cancer in the Korean population.

Original language	English
Pages (from-to)	3621-3627
Number of pages	7
Journal	Anticancer research
Volume	30
Issue number	9
Publication status	Published - 2010 Sept

Keywords

Haplotypes
Korean population
Lung cancer
Polymorphism
RET

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{16d2388268de49dc8e698765c128b972,

title = "A study of RET proto-oncogene polymorphisms in association with lung cancer risk in the Korean population",

abstract = "Background/Aim: This study examined whether the polymorphisms at the promoter region of RET gene are associated with the risk of lung cancer in the Korean population. Patients and Methods: A total of 409 Korean lung cancer patients and 409 normal subjects were recruited. PCR-RFLP, SNaP Shot assay and logistic regression analyses were performed to characterize the association between polymorphisms of RET and lung cancer risk. Results: Four SNPs (-1697 C>G, -1260 C>T, -719 C>T, -527 C>A) of RET were selected for large-scale genotyping. Statistical analyses revealed that novel -1260 C > T polymorphism and haplotype 3 (-1697G, -1260T, -719C, and -719C) were associated with the risk of lung cancer; specifically, there were significant associations within subgroups of males and smokers. Conclusion: These results demonstrated that this novel polymorphism of the RET gene is associated with an increased risk of lung cancer in the Korean population.",

keywords = "Haplotypes, Korean population, Lung cancer, Polymorphism, RET",

author = "Kim, {Hyun Kyung} and Jung, {Hae Yun} and Seungjoon Lim and Sung, {Jae Sook} and Whang, {Young Mi} and Ukhyun Jo and Lee, {Jong Eun} and Shin, {Sang Won} and Kim, {Jun Suk} and Ryu, {Jeong Seon} and Kim, {Yeul Hong}",

year = "2010",

month = sep,

language = "English",

volume = "30",

pages = "3621--3627",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "9",

}

TY - JOUR

T1 - A study of RET proto-oncogene polymorphisms in association with lung cancer risk in the Korean population

AU - Kim, Hyun Kyung

AU - Jung, Hae Yun

AU - Lim, Seungjoon

AU - Sung, Jae Sook

AU - Whang, Young Mi

AU - Jo, Ukhyun

AU - Lee, Jong Eun

AU - Shin, Sang Won

AU - Kim, Jun Suk

AU - Ryu, Jeong Seon

AU - Kim, Yeul Hong

PY - 2010/9

Y1 - 2010/9

N2 - Background/Aim: This study examined whether the polymorphisms at the promoter region of RET gene are associated with the risk of lung cancer in the Korean population. Patients and Methods: A total of 409 Korean lung cancer patients and 409 normal subjects were recruited. PCR-RFLP, SNaP Shot assay and logistic regression analyses were performed to characterize the association between polymorphisms of RET and lung cancer risk. Results: Four SNPs (-1697 C>G, -1260 C>T, -719 C>T, -527 C>A) of RET were selected for large-scale genotyping. Statistical analyses revealed that novel -1260 C > T polymorphism and haplotype 3 (-1697G, -1260T, -719C, and -719C) were associated with the risk of lung cancer; specifically, there were significant associations within subgroups of males and smokers. Conclusion: These results demonstrated that this novel polymorphism of the RET gene is associated with an increased risk of lung cancer in the Korean population.

AB - Background/Aim: This study examined whether the polymorphisms at the promoter region of RET gene are associated with the risk of lung cancer in the Korean population. Patients and Methods: A total of 409 Korean lung cancer patients and 409 normal subjects were recruited. PCR-RFLP, SNaP Shot assay and logistic regression analyses were performed to characterize the association between polymorphisms of RET and lung cancer risk. Results: Four SNPs (-1697 C>G, -1260 C>T, -719 C>T, -527 C>A) of RET were selected for large-scale genotyping. Statistical analyses revealed that novel -1260 C > T polymorphism and haplotype 3 (-1697G, -1260T, -719C, and -719C) were associated with the risk of lung cancer; specifically, there were significant associations within subgroups of males and smokers. Conclusion: These results demonstrated that this novel polymorphism of the RET gene is associated with an increased risk of lung cancer in the Korean population.

KW - Haplotypes

KW - Korean population

KW - Lung cancer

KW - Polymorphism

KW - RET

UR - http://www.scopus.com/inward/record.url?scp=77958551280&partnerID=8YFLogxK

M3 - Article

C2 - 20944145

AN - SCOPUS:77958551280

SN - 0250-7005

VL - 30

SP - 3621

EP - 3627

JO - Anticancer Research

JF - Anticancer Research

IS - 9

ER -

A study of RET proto-oncogene polymorphisms in association with lung cancer risk in the Korean population

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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