A study of RET proto-oncogene polymorphisms in association with lung cancer risk in the Korean population

Hyun Kyung Kim, Hae Yun Jung, Seungjoon Lim, Jae Sook Sung, Young Mi Whang, Ukhyun Jo, Jong Eun Lee, Sang Won Shin, Jun Suk Kim, Jeong Seon Ryu, Yeul Hong Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background/Aim: This study examined whether the polymorphisms at the promoter region of RET gene are associated with the risk of lung cancer in the Korean population. Patients and Methods: A total of 409 Korean lung cancer patients and 409 normal subjects were recruited. PCR-RFLP, SNaP Shot assay and logistic regression analyses were performed to characterize the association between polymorphisms of RET and lung cancer risk. Results: Four SNPs (-1697 C>G, -1260 C>T, -719 C>T, -527 C>A) of RET were selected for large-scale genotyping. Statistical analyses revealed that novel -1260 C > T polymorphism and haplotype 3 (-1697G, -1260T, -719C, and -719C) were associated with the risk of lung cancer; specifically, there were significant associations within subgroups of males and smokers. Conclusion: These results demonstrated that this novel polymorphism of the RET gene is associated with an increased risk of lung cancer in the Korean population.

Original languageEnglish
Pages (from-to)3621-3627
Number of pages7
JournalAnticancer Research
Volume30
Issue number9
Publication statusPublished - 2010 Sep 1

Fingerprint

Proto-Oncogenes
Polymorphism
Lung Neoplasms
Association reactions
Population
Genes
Genetic Promoter Regions
Logistics
Assays
Restriction Fragment Length Polymorphisms
Haplotypes
Single Nucleotide Polymorphism
Logistic Models
Regression Analysis
Polymerase Chain Reaction

Keywords

  • Haplotypes
  • Korean population
  • Lung cancer
  • Polymorphism
  • RET

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kim, H. K., Jung, H. Y., Lim, S., Sung, J. S., Whang, Y. M., Jo, U., ... Kim, Y. H. (2010). A study of RET proto-oncogene polymorphisms in association with lung cancer risk in the Korean population. Anticancer Research, 30(9), 3621-3627.

A study of RET proto-oncogene polymorphisms in association with lung cancer risk in the Korean population. / Kim, Hyun Kyung; Jung, Hae Yun; Lim, Seungjoon; Sung, Jae Sook; Whang, Young Mi; Jo, Ukhyun; Lee, Jong Eun; Shin, Sang Won; Kim, Jun Suk; Ryu, Jeong Seon; Kim, Yeul Hong.

In: Anticancer Research, Vol. 30, No. 9, 01.09.2010, p. 3621-3627.

Research output: Contribution to journalArticle

Kim, HK, Jung, HY, Lim, S, Sung, JS, Whang, YM, Jo, U, Lee, JE, Shin, SW, Kim, JS, Ryu, JS & Kim, YH 2010, 'A study of RET proto-oncogene polymorphisms in association with lung cancer risk in the Korean population', Anticancer Research, vol. 30, no. 9, pp. 3621-3627.
Kim HK, Jung HY, Lim S, Sung JS, Whang YM, Jo U et al. A study of RET proto-oncogene polymorphisms in association with lung cancer risk in the Korean population. Anticancer Research. 2010 Sep 1;30(9):3621-3627.
Kim, Hyun Kyung ; Jung, Hae Yun ; Lim, Seungjoon ; Sung, Jae Sook ; Whang, Young Mi ; Jo, Ukhyun ; Lee, Jong Eun ; Shin, Sang Won ; Kim, Jun Suk ; Ryu, Jeong Seon ; Kim, Yeul Hong. / A study of RET proto-oncogene polymorphisms in association with lung cancer risk in the Korean population. In: Anticancer Research. 2010 ; Vol. 30, No. 9. pp. 3621-3627.
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