A thermosensitive chitosan-based hydrogel for controlled release of insulin

Ting Ting Gao, Ming Kong, Xiao Jie Cheng, Gui Xue Xia, Yuan Yuan Gao, Xi Guang Chen, Dong Su Cha, Hyun Jin Park

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan (HBC) hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25°C. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells (L929). Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48 h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.

Original languageEnglish
Pages (from-to)142-149
Number of pages8
JournalFrontiers of Materials Science
Volume8
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

ASJC Scopus subject areas

  • Materials Science(all)

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  • Cite this

    Gao, T. T., Kong, M., Cheng, X. J., Xia, G. X., Gao, Y. Y., Chen, X. G., Cha, D. S., & Park, H. J. (2014). A thermosensitive chitosan-based hydrogel for controlled release of insulin. Frontiers of Materials Science, 8(2), 142-149. https://doi.org/10.1007/s11706-014-0247-7