A thermosensitive chitosan-based hydrogel for controlled release of insulin

Ting Ting Gao; Ming Kong; Xiao Jie Cheng; Gui Xue Xia; Yuan Yuan Gao; Xi Guang Chen; Dong Su Cha; Hyun Jin Park

doi:10.1007/s11706-014-0247-7

A thermosensitive chitosan-based hydrogel for controlled release of insulin

Ting Ting Gao, Ming Kong, Xiao Jie Cheng, Gui Xue Xia, Yuan Yuan Gao, Xi Guang Chen, Dong Su Cha, Hyun Jin Park

Department of Biotechnology

Research output: Contribution to journal › Article

11 Citations (Scopus)

Abstract

Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan (HBC) hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25°C. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells (L929). Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48 h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.

Original language	English
Pages (from-to)	142-149
Number of pages	8
Journal	Frontiers of Materials Science
Volume	8
Issue number	2
DOIs	https://doi.org/10.1007/s11706-014-0247-7
Publication status	Published - 2014 Jan 1

ASJC Scopus subject areas

Materials Science(all)

Access to Document

10.1007/s11706-014-0247-7

Fingerprint Dive into the research topics of 'A thermosensitive chitosan-based hydrogel for controlled release of insulin'. Together they form a unique fingerprint.

Cite this

Gao, T. T., Kong, M., Cheng, X. J., Xia, G. X., Gao, Y. Y., Chen, X. G., Cha, D. S., & Park, H. J. (2014). A thermosensitive chitosan-based hydrogel for controlled release of insulin. Frontiers of Materials Science, 8(2), 142-149. https://doi.org/10.1007/s11706-014-0247-7

@article{17bbe9bd1a4b4ac2a81c3d85e0f03f8c,

title = "A thermosensitive chitosan-based hydrogel for controlled release of insulin",

abstract = "Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan (HBC) hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25°C. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells (L929). Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48 h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.",

keywords = "Controlled release, Hydrogel, Hydroxybutyl chitosan, Insulin, Thermosensitive",

author = "Gao, {Ting Ting} and Ming Kong and Cheng, {Xiao Jie} and Xia, {Gui Xue} and Gao, {Yuan Yuan} and Chen, {Xi Guang} and Cha, {Dong Su} and Park, {Hyun Jin}",

year = "2014",

month = jan,

day = "1",

doi = "10.1007/s11706-014-0247-7",

language = "English",

volume = "8",

pages = "142--149",

journal = "Frontiers of Materials Science",

issn = "2095-025X",

publisher = "Higher Education Press",

number = "2",

}

TY - JOUR

T1 - A thermosensitive chitosan-based hydrogel for controlled release of insulin

AU - Gao, Ting Ting

AU - Kong, Ming

AU - Cheng, Xiao Jie

AU - Xia, Gui Xue

AU - Gao, Yuan Yuan

AU - Chen, Xi Guang

AU - Cha, Dong Su

AU - Park, Hyun Jin

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan (HBC) hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25°C. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells (L929). Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48 h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.

AB - Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan (HBC) hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25°C. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells (L929). Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48 h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.

KW - Controlled release

KW - Hydrogel

KW - Hydroxybutyl chitosan

KW - Insulin

KW - Thermosensitive

UR - http://www.scopus.com/inward/record.url?scp=84905962625&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905962625&partnerID=8YFLogxK

U2 - 10.1007/s11706-014-0247-7

DO - 10.1007/s11706-014-0247-7

M3 - Article

AN - SCOPUS:84905962625

VL - 8

SP - 142

EP - 149

JO - Frontiers of Materials Science

JF - Frontiers of Materials Science

SN - 2095-025X

IS - 2

ER -