Abstract
Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan (HBC) hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25°C. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells (L929). Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48 h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.
| Original language | English |
|---|---|
| Pages (from-to) | 142-149 |
| Number of pages | 8 |
| Journal | Frontiers of Materials Science |
| Volume | 8 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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ASJC Scopus subject areas
- Materials Science(all)
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A thermosensitive chitosan-based hydrogel for controlled release of insulin. / Gao, Ting Ting; Kong, Ming; Cheng, Xiao Jie; Xia, Gui Xue; Gao, Yuan Yuan; Chen, Xi Guang; Cha, Dong Su; Park, Hyun Jin.
In: Frontiers of Materials Science, Vol. 8, No. 2, 01.01.2014, p. 142-149.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A thermosensitive chitosan-based hydrogel for controlled release of insulin
AU - Gao, Ting Ting
AU - Kong, Ming
AU - Cheng, Xiao Jie
AU - Xia, Gui Xue
AU - Gao, Yuan Yuan
AU - Chen, Xi Guang
AU - Cha, Dong Su
AU - Park, Hyun Jin
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan (HBC) hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25°C. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells (L929). Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48 h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.
AB - Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan (HBC) hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25°C. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells (L929). Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48 h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.
KW - Controlled release
KW - Hydrogel
KW - Hydroxybutyl chitosan
KW - Insulin
KW - Thermosensitive
UR - http://www.scopus.com/inward/record.url?scp=84905962625&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905962625&partnerID=8YFLogxK
U2 - 10.1007/s11706-014-0247-7
DO - 10.1007/s11706-014-0247-7
M3 - Article
AN - SCOPUS:84905962625
VL - 8
SP - 142
EP - 149
JO - Frontiers of Materials Science
JF - Frontiers of Materials Science
SN - 2095-025X
IS - 2
ER -