Abstract
Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan (HBC) hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25°C. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells (L929). Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48 h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.
Original language | English |
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Pages (from-to) | 142-149 |
Number of pages | 8 |
Journal | Frontiers of Materials Science |
Volume | 8 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2014 Jun |
Keywords
- Controlled release
- Hydrogel
- Hydroxybutyl chitosan
- Insulin
- Thermosensitive
ASJC Scopus subject areas
- Materials Science(all)