A thermosensitive chitosan-based hydrogel for controlled release of insulin

Ting Ting Gao; Ming Kong; Xiao Jie Cheng; Gui Xue Xia; Yuan Yuan Gao; Xi Guang Chen; Dong Su Cha; Hyun Jin Park

doi:10.1007/s11706-014-0247-7

A thermosensitive chitosan-based hydrogel for controlled release of insulin

Ting Ting Gao, Ming Kong, Xiao Jie Cheng, Gui Xue Xia, Yuan Yuan Gao, Xi Guang Chen, Dong Su Cha, Hyun Jin Park

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan (HBC) hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25°C. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells (L929). Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48 h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.

Original language	English
Pages (from-to)	142-149
Number of pages	8
Journal	Frontiers of Materials Science
Volume	8
Issue number	2
DOIs	https://doi.org/10.1007/s11706-014-0247-7
Publication status	Published - 2014 Jun

Keywords

Controlled release
Hydrogel
Hydroxybutyl chitosan
Insulin
Thermosensitive

ASJC Scopus subject areas

Materials Science(all)

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10.1007/s11706-014-0247-7

Cite this

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title = "A thermosensitive chitosan-based hydrogel for controlled release of insulin",

abstract = "Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan (HBC) hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25°C. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells (L929). Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48 h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.",

keywords = "Controlled release, Hydrogel, Hydroxybutyl chitosan, Insulin, Thermosensitive",

author = "Gao, {Ting Ting} and Ming Kong and Cheng, {Xiao Jie} and Xia, {Gui Xue} and Gao, {Yuan Yuan} and Chen, {Xi Guang} and Cha, {Dong Su} and Park, {Hyun Jin}",

note = "Funding Information: Acknowledgements This work was supported by a grant from International S&T Cooperation Program of China (Grant No. 2013DFG32880), the National Natural Science Foundation of China (Grant No. 31000423), and the Doctoral Fund of Ministry of Education of China (Grant No. 20120132110012)",

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doi = "10.1007/s11706-014-0247-7",

language = "English",

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pages = "142--149",

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AU - Gao, Ting Ting

AU - Kong, Ming

AU - Cheng, Xiao Jie

AU - Xia, Gui Xue

AU - Gao, Yuan Yuan

AU - Chen, Xi Guang

AU - Cha, Dong Su

AU - Park, Hyun Jin

N1 - Funding Information: Acknowledgements This work was supported by a grant from International S&T Cooperation Program of China (Grant No. 2013DFG32880), the National Natural Science Foundation of China (Grant No. 31000423), and the Doctoral Fund of Ministry of Education of China (Grant No. 20120132110012)

PY - 2014/6

Y1 - 2014/6

N2 - Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan (HBC) hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25°C. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells (L929). Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48 h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.

AB - Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan (HBC) hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25°C. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells (L929). Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48 h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.

KW - Controlled release

KW - Hydrogel

KW - Hydroxybutyl chitosan

KW - Insulin

KW - Thermosensitive

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ER -

A thermosensitive chitosan-based hydrogel for controlled release of insulin

Abstract

Keywords

ASJC Scopus subject areas

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