A three-dimensional and sensitive bioassay based on nanostructured quartz combined with viral nanoparticles

Jong Hwan Lee, Jung Suk Kim, Jin Seung Park, Wonbae Lee, Kyung Eun Lee, Sung Sik Han, Kyu Back Lee, Jeewon Lee

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

An effective mask-free method for fabricating high-aspect-ratio pillarlike nanostructures over a large area of a quartz surface via a simple O2 and CF4 two-step reactive ion etching (RIE) procedure is developed. The nanostructured quartz surfaces are successfully combined with the engineered viral particles derived from hepatitis B virus capsid, yielding a novel 3D assay system with attomolar sensitivity, which has great potential for use in sensitive and early detection of various disease markers.

Original languageEnglish
Pages (from-to)2004-2009
Number of pages6
JournalAdvanced Functional Materials
Volume20
Issue number12
DOIs
Publication statusPublished - 2010 Jun 23

Fingerprint

bioassay
Quartz
Bioassay
quartz
Nanoparticles
hepatitis
nanoparticles
Reactive ion etching
viruses
high aspect ratio
Viruses
markers
Aspect ratio
Masks
Assays
Nanostructures
masks
etching
sensitivity
ions

ASJC Scopus subject areas

  • Biomaterials
  • Electrochemistry
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

A three-dimensional and sensitive bioassay based on nanostructured quartz combined with viral nanoparticles. / Lee, Jong Hwan; Kim, Jung Suk; Park, Jin Seung; Lee, Wonbae; Lee, Kyung Eun; Han, Sung Sik; Lee, Kyu Back; Lee, Jeewon.

In: Advanced Functional Materials, Vol. 20, No. 12, 23.06.2010, p. 2004-2009.

Research output: Contribution to journalArticle

Lee, Jong Hwan ; Kim, Jung Suk ; Park, Jin Seung ; Lee, Wonbae ; Lee, Kyung Eun ; Han, Sung Sik ; Lee, Kyu Back ; Lee, Jeewon. / A three-dimensional and sensitive bioassay based on nanostructured quartz combined with viral nanoparticles. In: Advanced Functional Materials. 2010 ; Vol. 20, No. 12. pp. 2004-2009.
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