A three-dimensional and sensitive bioassay based on nanostructured quartz combined with viral nanoparticles

Jong Hwan Lee, Jung Suk Kim, Jin Seung Park, Wonbae Lee, Kyung Eun Lee, Sung Sik Han, Kyu Back Lee, Jeewon Lee

Research output: Contribution to journalArticle

30 Citations (Scopus)


An effective mask-free method for fabricating high-aspect-ratio pillarlike nanostructures over a large area of a quartz surface via a simple O2 and CF4 two-step reactive ion etching (RIE) procedure is developed. The nanostructured quartz surfaces are successfully combined with the engineered viral particles derived from hepatitis B virus capsid, yielding a novel 3D assay system with attomolar sensitivity, which has great potential for use in sensitive and early detection of various disease markers.

Original languageEnglish
Pages (from-to)2004-2009
Number of pages6
JournalAdvanced Functional Materials
Issue number12
Publication statusPublished - 2010 Jun 23


ASJC Scopus subject areas

  • Biomaterials
  • Electrochemistry
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

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