A three-dimensional in vitro model of lymphangiogenesis in tumor microenvironment

Youngkyu Cho, Kyuhwan Na, Jihee Won, Yesl Jun, Ji Hun Yang, Seok Chung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here, we presented ECM incorporated new macro-fluidic platform for physiological relevant lymphangiogenesis model which has lumen structure and button-like junctions. Using this model, we successfully developed tumor microenvironment applying cancer spheroid which has hypoxic core. Interestingly, vascular endothelial growth factors (VEGFs) combination and induced interstitial flow in tumor site facilitate lymphangiogensis and promote cancer metastasis. Furthermore, this platform has a possibility for adaptive immune model since DC shows migration to new lymphatic vessel and transmigration through the lymphatic endothelium. Moreover, the macro-fluidic platform can be performed biological analysis on a chip, such as qRT-PCR, western blot, ELISA, immunostaining and monitoring in real time for cell development and migration.

Original languageEnglish
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages245-247
Number of pages3
ISBN (Electronic)9781510897571
Publication statusPublished - 2018 Jan 1
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: 2018 Nov 112018 Nov 15

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume1

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period18/11/1118/11/15

Keywords

  • Lymphangiognesis
  • Tumor microenvironment

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

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