A three-dimensional model of fluid-structural interactions for quantifying the contractile force for cardiomyocytes on hybrid biopolymer microcantilever

Jungyul Park, Suk Kyu Ryu, Jinseok Kim, Junghun Cha, Jeongeun Baek, Sukho Park, Byungkyu Kim, Sang Ho Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Quantitatively analysis of the contractility of cardiomyocytes is important for understanding the mechanism of heart failure as well as the molecular alterations in diseased heart cells. This paper presents a realistic computational model, which considers the three-dimensional fluid-structural interactions (FSI), to quantify the contractile force of cardiomyocytes on hybrid biopolymer microcantilevers. Prior to this study, only static modeling of the microscale cellular force has been reported. This study modeled the dynamics of cardiomyocytes on microcantilevers in a medium using the FSI. This realistic model was compared with static finite element modeling (FEM) analysis and the Stoney's equation-based analytical solution, and was validated by the deflections of the microcantilevers in the experimental results. Using harmonic response analysis in FSI modeling, the motion of a hybrid biopolymer microcantilever in the medium was identified as a second-order system and the influence of the dynamics of cardiomyocytes could be evaluated quantitatively.

Original languageEnglish
Pages (from-to)2823-2830
Number of pages8
JournalJournal of Biomechanics
Volume40
Issue number13
DOIs
Publication statusPublished - 2007

Keywords

  • Cardiomyocyte
  • Contractile force
  • FEM
  • Fluid-structure interactions
  • Microcantilever

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

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