A Tubulin inhibitor, N-(5-benzyl-1,3-thiazol-2-yl)-3-(furan-2-yl)prop-2-enamide, induces anti-inflammatory innate immune responses to attenuate LPS-mediated septic shock

Hyun Jung Park, Sung Won Lee, Hwangseo Park, Se-Ho Park, Seokmann Hong

Research output: Contribution to journalArticle

Abstract

The anti-inflammatory effect of a tubulin inhibitor, N-(5-benzyl-1,3-thiazol-2-yl)-3-(furan-2-yl)prop-2-enamide (1), on innate immune responses remains unclear. Thus, we investigated the effect of 1 on the immune responses mediated by lipopolysaccharide (LPS). The in vitro addition of 1 to dendritic cells and macrophages dose-dependently reduced tumor necrosis factor alpha production elicited by LPS stimulation. Additionally, the stimulation of natural killer (NK) and natural killer T (NKT) cells with 1 resulted in the decrease of interferon gamma (IFNγ) induced by LPS treatment. Moreover, 1 substantially reduced interleukin 12 in dendritic cells (DC) as well as IFNγ in NKDCs induced by LPS in vitro. Furthermore, the in vivo administration of 1 ameliorated LPS/D-galactosamine-induced endotoxic lethality in mice. Taken together, our results demonstrate for the first time that 1 possesses anti-inflammatory properties, most notably by modulating LPS-induced innate immune responses. Therefore, 1 might have therapeutic potential for the treatment of inflammation-mediated diseases such as sepsis.

Original languageEnglish
Pages (from-to)3307-3312
Number of pages6
JournalBulletin of the Korean Chemical Society
Volume35
Issue number11
DOIs
Publication statusPublished - 2014 Nov 20

    Fingerprint

Keywords

  • Anti-inflammatory
  • Anticancer
  • N-(5-benzyl-1,3-thiazol-2-yl)-3-(furan-2-yl)prop-2-enamide
  • Sepsis
  • Tubulin inhibitor

ASJC Scopus subject areas

  • Chemistry(all)

Cite this