A variant t(8;10;21) in a patient with pathological features mimicking atypical chronic myeloid leukemia

Ji-Yun Lee, William F. Kern, Joan B. Cain, John J. Mulvihill, Shibo Li

Research output: Contribution to journalArticle

5 Citations (Scopus)


We report the case of an 11-year-old girl who was initially diagnosed with a chronic myeloproliferative disorder, possibly chronic myelogenous leukemia (CML), based on laboratory and blood and marrow morphological findings. The patient's high leukocyte count did not respond to hydroxyurea, a standard initial therapy for CML. Chromosomal analysis revealed that the patient did not have t(9;22), but a complex t(8;10;21)(q22;q24;q22), a variant of t(8;21). The treatment regime was switched to an acute myeloid leukemia (AML) protocol; the patient responded well and is now in remission. This case demonstrates again that routine clinical cytogenetic analysis plays an important role in the clinical diagnosis, guidance of treatment, and prognostication in hematological disorders.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalCancer Genetics and Cytogenetics
Issue number1
Publication statusPublished - 2005 Jan 1
Externally publishedYes


ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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