A variant t(8;10;21) in a patient with pathological features mimicking atypical chronic myeloid leukemia

Jiyun Lee; William F. Kern; Joan B. Cain; John J. Mulvihill; Shibo Li

doi:10.1016/j.cancergencyto.2004.10.002

A variant t(8;10;21) in a patient with pathological features mimicking atypical chronic myeloid leukemia

Jiyun Lee, William F. Kern, Joan B. Cain, John J. Mulvihill, Shibo Li

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

We report the case of an 11-year-old girl who was initially diagnosed with a chronic myeloproliferative disorder, possibly chronic myelogenous leukemia (CML), based on laboratory and blood and marrow morphological findings. The patient's high leukocyte count did not respond to hydroxyurea, a standard initial therapy for CML. Chromosomal analysis revealed that the patient did not have t(9;22), but a complex t(8;10;21)(q22;q24;q22), a variant of t(8;21). The treatment regime was switched to an acute myeloid leukemia (AML) protocol; the patient responded well and is now in remission. This case demonstrates again that routine clinical cytogenetic analysis plays an important role in the clinical diagnosis, guidance of treatment, and prognostication in hematological disorders.

Original language	English
Pages (from-to)	79-83
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	159
Issue number	1
DOIs	https://doi.org/10.1016/j.cancergencyto.2004.10.002
Publication status	Published - 2005 May
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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Lee, J., Kern, W. F., Cain, J. B., Mulvihill, J. J., & Li, S. (2005). A variant t(8;10;21) in a patient with pathological features mimicking atypical chronic myeloid leukemia. Cancer Genetics and Cytogenetics, 159(1), 79-83. https://doi.org/10.1016/j.cancergencyto.2004.10.002

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abstract = "We report the case of an 11-year-old girl who was initially diagnosed with a chronic myeloproliferative disorder, possibly chronic myelogenous leukemia (CML), based on laboratory and blood and marrow morphological findings. The patient's high leukocyte count did not respond to hydroxyurea, a standard initial therapy for CML. Chromosomal analysis revealed that the patient did not have t(9;22), but a complex t(8;10;21)(q22;q24;q22), a variant of t(8;21). The treatment regime was switched to an acute myeloid leukemia (AML) protocol; the patient responded well and is now in remission. This case demonstrates again that routine clinical cytogenetic analysis plays an important role in the clinical diagnosis, guidance of treatment, and prognostication in hematological disorders.",

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