Abstract
We report the case of an 11-year-old girl who was initially diagnosed with a chronic myeloproliferative disorder, possibly chronic myelogenous leukemia (CML), based on laboratory and blood and marrow morphological findings. The patient's high leukocyte count did not respond to hydroxyurea, a standard initial therapy for CML. Chromosomal analysis revealed that the patient did not have t(9;22), but a complex t(8;10;21)(q22;q24;q22), a variant of t(8;21). The treatment regime was switched to an acute myeloid leukemia (AML) protocol; the patient responded well and is now in remission. This case demonstrates again that routine clinical cytogenetic analysis plays an important role in the clinical diagnosis, guidance of treatment, and prognostication in hematological disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 79-83 |
| Number of pages | 5 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 159 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2005 Jan 1 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research
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A variant t(8;10;21) in a patient with pathological features mimicking atypical chronic myeloid leukemia. / Lee, Ji-Yun; Kern, William F.; Cain, Joan B.; Mulvihill, John J.; Li, Shibo.
In: Cancer Genetics and Cytogenetics, Vol. 159, No. 1, 01.01.2005, p. 79-83.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A variant t(8;10;21) in a patient with pathological features mimicking atypical chronic myeloid leukemia
AU - Lee, Ji-Yun
AU - Kern, William F.
AU - Cain, Joan B.
AU - Mulvihill, John J.
AU - Li, Shibo
PY - 2005/1/1
Y1 - 2005/1/1
N2 - We report the case of an 11-year-old girl who was initially diagnosed with a chronic myeloproliferative disorder, possibly chronic myelogenous leukemia (CML), based on laboratory and blood and marrow morphological findings. The patient's high leukocyte count did not respond to hydroxyurea, a standard initial therapy for CML. Chromosomal analysis revealed that the patient did not have t(9;22), but a complex t(8;10;21)(q22;q24;q22), a variant of t(8;21). The treatment regime was switched to an acute myeloid leukemia (AML) protocol; the patient responded well and is now in remission. This case demonstrates again that routine clinical cytogenetic analysis plays an important role in the clinical diagnosis, guidance of treatment, and prognostication in hematological disorders.
AB - We report the case of an 11-year-old girl who was initially diagnosed with a chronic myeloproliferative disorder, possibly chronic myelogenous leukemia (CML), based on laboratory and blood and marrow morphological findings. The patient's high leukocyte count did not respond to hydroxyurea, a standard initial therapy for CML. Chromosomal analysis revealed that the patient did not have t(9;22), but a complex t(8;10;21)(q22;q24;q22), a variant of t(8;21). The treatment regime was switched to an acute myeloid leukemia (AML) protocol; the patient responded well and is now in remission. This case demonstrates again that routine clinical cytogenetic analysis plays an important role in the clinical diagnosis, guidance of treatment, and prognostication in hematological disorders.
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UR - http://www.scopus.com/inward/citedby.url?scp=18244394787&partnerID=8YFLogxK
U2 - 10.1016/j.cancergencyto.2004.10.002
DO - 10.1016/j.cancergencyto.2004.10.002
M3 - Article
C2 - 15860363
AN - SCOPUS:18244394787
VL - 159
SP - 79
EP - 83
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -