Abdominal and Pelvic Organ Failure Induced by Intraperitoneal Influenza A Virus Infection in Mice

Avishekh Gautam, Madhav Akauliya, Bikash Thapa, Byoung Kwon Park, Dongbum Kim, Jinsoo Kim, Keunwook Lee, Kyung Chan Choi, Joon Yong Bae, Man Seong Park, Younghee Lee, Hyung Joo Kwon

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


In humans, respiratory infections with influenza A viruses can be lethal, but it is unclear whether non-respiratory influenza A infections can be equally lethal. Intraperitoneal infection makes the abdominal and pelvic organs accessible to pathogens because of the circulation of peritoneal fluid throughout the pelvis and abdomen. We found that high-dose intraperitoneal infection in mice with influenza A viruses resulted in severe sclerosis and structural damage in the pancreas, disruption of ovarian follicles, and massive infiltration of immune cells in the uterus. The intraperitoneal infections also caused robust upregulation of proinflammatory mediators including IL-6, BLC, and MIG. In addition, low-dose intraperitoneal infection with one influenza strain provided cross-protection against subsequent intraperitoneal or intranasal challenge with another influenza strain. Our results suggest that low-dose, non-respiratory administration might provide a route for influenza vaccination. Furthermore, these results provide insight on the pathological role of influenza A viruses in high-risk patients, including women and diabetic individuals.

Original languageEnglish
Article number1713
JournalFrontiers in Microbiology
Publication statusPublished - 2020 Jul 17


  • abdominal organs
  • chemokines
  • cytokines
  • infection
  • influenza A virus
  • organ failure

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


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