Abdominal obesity as a risk factor for the development of erosive esophagitis in subjects with a normal esophago-gastric junction

Ja Seol Koo, Sang Woo Lee, Sun Min Park, Sung Woo Jung, Hyung Joon Yim, Jong Jae Park, Hoon Jai Chun, Hong Sik Lee, Jai Hyun Choi, Chang Duck Kim, Ho Sang Ryu

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Background/Aims: Obesity is reported to be associated with erosive esophagitis (EE). However, the temporal association of obesity and abdominal obesity with EE is unclear. We conducted this study to investigate the temporal association of obesity, especially abdominal obesity with EE. Methods: Among 1,182 subjects who underwent health screening examinations including upper endoscopy in both 2003 and 2006, a total 1,029 subjects with a normal esophagogastric junction on upper endoscopy in 2003 were enrolled. All subjects completed questionnaires and anthropometric measurements were obtained twice by trained personnels. The patients with newly developed EE were compared to the subjects without newly developed EE. Results: Among 1,029 subjects, 42 (4.1%) were newly diagnosed with EE and 82 (8.0%) with hiatal hernia. The mean body mass index (BMI) in both examinations was significantly different between the two groups based on the development of erosive esophagitis (p<0.05 in both examinations). The mean waist circumference (WC) in both examinations was also significantly different between the two groups (p<0.01 in both examinations). The multivariate analysis demonstrated that EE was not associated with the BMI in 2003 and the increase of BMI; however, it was associated with the WC in 2003 (Odds ratio, 7.21; 95% CI, 1.78 to 29.19; <90 cm vs <80 cm). Conclusions: Our study showed that abdominal circumference is an independent risk factor for EE, demonstrating a temporal relationship between abdominal obesity and EE.

Original languageEnglish
Pages (from-to)276-284
Number of pages9
JournalGut and liver
Issue number4
Publication statusPublished - 2009 Dec 1



  • Abdominal obesity
  • Causality
  • Erosive esophagitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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