Abdominal obesity as a risk factor for the development of erosive esophagitis in subjects with a normal esophago-gastric junction

Ja Seol Koo, Sang Woo Lee, Sun Min Park, Sung Woo Jung, Hyung Joon Yim, Jong Jae Park, Hoon-Jai Chun, Hong Sik Lee, Jai Hyun Choi, Chang Duck Kim, Ho Sang Ryu

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5 Citations (Scopus)

Abstract

Background/Aims: Obesity is reported to be associated with erosive esophagitis (EE). However, the temporal association of obesity and abdominal obesity with EE is unclear. We conducted this study to investigate the temporal association of obesity, especially abdominal obesity with EE. Methods: Among 1,182 subjects who underwent health screening examinations including upper endoscopy in both 2003 and 2006, a total 1,029 subjects with a normal esophagogastric junction on upper endoscopy in 2003 were enrolled. All subjects completed questionnaires and anthropometric measurements were obtained twice by trained personnels. The patients with newly developed EE were compared to the subjects without newly developed EE. Results: Among 1,029 subjects, 42 (4.1%) were newly diagnosed with EE and 82 (8.0%) with hiatal hernia. The mean body mass index (BMI) in both examinations was significantly different between the two groups based on the development of erosive esophagitis (p<0.05 in both examinations). The mean waist circumference (WC) in both examinations was also significantly different between the two groups (p<0.01 in both examinations). The multivariate analysis demonstrated that EE was not associated with the BMI in 2003 and the increase of BMI; however, it was associated with the WC in 2003 (Odds ratio, 7.21; 95% CI, 1.78 to 29.19; <90 cm vs <80 cm). Conclusions: Our study showed that abdominal circumference is an independent risk factor for EE, demonstrating a temporal relationship between abdominal obesity and EE.

Original languageEnglish
Pages (from-to)276-284
Number of pages9
JournalGut and Liver
Volume3
Issue number4
DOIs
Publication statusPublished - 2009 Dec 1

Fingerprint

Esophagitis
Abdominal Obesity
Stomach
Body Mass Index
Obesity
Waist Circumference
Endoscopy
Esophagogastric Junction
Hiatal Hernia
Multivariate Analysis
Odds Ratio

Keywords

  • Abdominal obesity
  • Causality
  • Erosive esophagitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

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title = "Abdominal obesity as a risk factor for the development of erosive esophagitis in subjects with a normal esophago-gastric junction",
abstract = "Background/Aims: Obesity is reported to be associated with erosive esophagitis (EE). However, the temporal association of obesity and abdominal obesity with EE is unclear. We conducted this study to investigate the temporal association of obesity, especially abdominal obesity with EE. Methods: Among 1,182 subjects who underwent health screening examinations including upper endoscopy in both 2003 and 2006, a total 1,029 subjects with a normal esophagogastric junction on upper endoscopy in 2003 were enrolled. All subjects completed questionnaires and anthropometric measurements were obtained twice by trained personnels. The patients with newly developed EE were compared to the subjects without newly developed EE. Results: Among 1,029 subjects, 42 (4.1{\%}) were newly diagnosed with EE and 82 (8.0{\%}) with hiatal hernia. The mean body mass index (BMI) in both examinations was significantly different between the two groups based on the development of erosive esophagitis (p<0.05 in both examinations). The mean waist circumference (WC) in both examinations was also significantly different between the two groups (p<0.01 in both examinations). The multivariate analysis demonstrated that EE was not associated with the BMI in 2003 and the increase of BMI; however, it was associated with the WC in 2003 (Odds ratio, 7.21; 95{\%} CI, 1.78 to 29.19; <90 cm vs <80 cm). Conclusions: Our study showed that abdominal circumference is an independent risk factor for EE, demonstrating a temporal relationship between abdominal obesity and EE.",
keywords = "Abdominal obesity, Causality, Erosive esophagitis",
author = "Koo, {Ja Seol} and Lee, {Sang Woo} and Park, {Sun Min} and Jung, {Sung Woo} and Yim, {Hyung Joon} and Park, {Jong Jae} and Hoon-Jai Chun and Lee, {Hong Sik} and Choi, {Jai Hyun} and Kim, {Chang Duck} and Ryu, {Ho Sang}",
year = "2009",
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day = "1",
doi = "10.5009/gnl.2009.3.4.276",
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pages = "276--284",
journal = "Gut and Liver",
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T1 - Abdominal obesity as a risk factor for the development of erosive esophagitis in subjects with a normal esophago-gastric junction

AU - Koo, Ja Seol

AU - Lee, Sang Woo

AU - Park, Sun Min

AU - Jung, Sung Woo

AU - Yim, Hyung Joon

AU - Park, Jong Jae

AU - Chun, Hoon-Jai

AU - Lee, Hong Sik

AU - Choi, Jai Hyun

AU - Kim, Chang Duck

AU - Ryu, Ho Sang

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Background/Aims: Obesity is reported to be associated with erosive esophagitis (EE). However, the temporal association of obesity and abdominal obesity with EE is unclear. We conducted this study to investigate the temporal association of obesity, especially abdominal obesity with EE. Methods: Among 1,182 subjects who underwent health screening examinations including upper endoscopy in both 2003 and 2006, a total 1,029 subjects with a normal esophagogastric junction on upper endoscopy in 2003 were enrolled. All subjects completed questionnaires and anthropometric measurements were obtained twice by trained personnels. The patients with newly developed EE were compared to the subjects without newly developed EE. Results: Among 1,029 subjects, 42 (4.1%) were newly diagnosed with EE and 82 (8.0%) with hiatal hernia. The mean body mass index (BMI) in both examinations was significantly different between the two groups based on the development of erosive esophagitis (p<0.05 in both examinations). The mean waist circumference (WC) in both examinations was also significantly different between the two groups (p<0.01 in both examinations). The multivariate analysis demonstrated that EE was not associated with the BMI in 2003 and the increase of BMI; however, it was associated with the WC in 2003 (Odds ratio, 7.21; 95% CI, 1.78 to 29.19; <90 cm vs <80 cm). Conclusions: Our study showed that abdominal circumference is an independent risk factor for EE, demonstrating a temporal relationship between abdominal obesity and EE.

AB - Background/Aims: Obesity is reported to be associated with erosive esophagitis (EE). However, the temporal association of obesity and abdominal obesity with EE is unclear. We conducted this study to investigate the temporal association of obesity, especially abdominal obesity with EE. Methods: Among 1,182 subjects who underwent health screening examinations including upper endoscopy in both 2003 and 2006, a total 1,029 subjects with a normal esophagogastric junction on upper endoscopy in 2003 were enrolled. All subjects completed questionnaires and anthropometric measurements were obtained twice by trained personnels. The patients with newly developed EE were compared to the subjects without newly developed EE. Results: Among 1,029 subjects, 42 (4.1%) were newly diagnosed with EE and 82 (8.0%) with hiatal hernia. The mean body mass index (BMI) in both examinations was significantly different between the two groups based on the development of erosive esophagitis (p<0.05 in both examinations). The mean waist circumference (WC) in both examinations was also significantly different between the two groups (p<0.01 in both examinations). The multivariate analysis demonstrated that EE was not associated with the BMI in 2003 and the increase of BMI; however, it was associated with the WC in 2003 (Odds ratio, 7.21; 95% CI, 1.78 to 29.19; <90 cm vs <80 cm). Conclusions: Our study showed that abdominal circumference is an independent risk factor for EE, demonstrating a temporal relationship between abdominal obesity and EE.

KW - Abdominal obesity

KW - Causality

KW - Erosive esophagitis

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DO - 10.5009/gnl.2009.3.4.276

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