Abnormal sphincter of oddi response to cholecystokinin in postcholecystectomy syndrome patients with irritable bowel syndrome - The irritable sphincter

Peter R. Evans, John F. Dowsett, Young-Tae Bak, Yiu Kay Chan, John E. Kellow

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Standard biliary manometry, including cholecystokinin (CCK) provocation, was performed on 42 consecutive patients (36 F, 6 M, median age 45 years) with postcholecystectomy syndrome (PCS) who had no evidence of organic disease but who had objective clinical features suggesting sphincter of Oddi dysfunction (SOD) (classes I and II). Patients were subdivided into those with (N=14) and without (N=28) irritable bowel syndrome (IBS) using a validated symptom questionnaire based on the modified Rome criteria. Resting sphincter of Oddi (SO) motor parameters (basal pressure, contractile amplitude and frequency, and proportion of retrograde contractions), the presence of abnormal manometry, and the presence of an abnormal response to CCK were compared in the two groups. No significant differences in resting parameters of SO motor activity between patients with and without IBS were observed, and abnormal biliary manometry as a whole was not more prevalent in either group (8/13 and 18/27, respectively). An abnormal response to CCK (failure of complete inhibition of phasic contractions), however, was demonstrated in five of 12 patients with IBS compared with only one of 23 patients without IBS (P=0.01). In patients with postcholecystectomy SOD, an abnormal response of the SO to CCK thus appears to be an important feature of the subset of patients with concomitant IBS.

Original languageEnglish
Pages (from-to)1149-1156
Number of pages8
JournalDigestive Diseases and Sciences
Volume40
Issue number5
DOIs
Publication statusPublished - 1995 May 1
Externally publishedYes

Keywords

  • biliary dyskinesia
  • cholecystokinin
  • irritable bowel syndrome

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Abnormal sphincter of oddi response to cholecystokinin in postcholecystectomy syndrome patients with irritable bowel syndrome - The irritable sphincter'. Together they form a unique fingerprint.

  • Cite this