Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain

Kyungsoon Chung, Hee Jin Kim, Heung Sik Na, Mae Ja Park, Jin Mo Chung

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Using the rat model that we have developed, a potential underlying mechanism for sympathetically maintained neuropathic pain (SMP) was explored. In rats showing neuropathic pain behaviors after a tight ligation of the L5 spinal nerve, putative sympathetic postganglionic fibers were examined in the injured spinal nerve and the dorsal root ganglion (DRG), using immunohistochemical staining with antibody against tyrosine hydroxylase (TH). In the neuropathic rats, there was an increase in the number of TH-immunolabeled fibers in the spinal nerve, and some DRG cells were surrounded by the labeled fibers. These abnormalities of sympathetic postganglionic innervation of the injured spinal nerve or the DRG may be a part of the mechanisms underlying the development of SMP.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalNeuroscience Letters
Volume162
Issue number1-2
Publication statusPublished - 1993 Nov 12
Externally publishedYes

Fingerprint

Spinal Nerves
Spinal Ganglia
Neuralgia
Peripheral Nerves
Tyrosine 3-Monooxygenase
Postganglionic Sympathetic Fibers
Spinal Nerve Roots
Ligation
Staining and Labeling
Antibodies

Keywords

  • Causalgia
  • Dorsal root ganglion
  • Hyperalgesia
  • Mechanical allodynia
  • Peripheral nerve injury
  • Sympathetically maintained pain
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain. / Chung, Kyungsoon; Kim, Hee Jin; Na, Heung Sik; Park, Mae Ja; Chung, Jin Mo.

In: Neuroscience Letters, Vol. 162, No. 1-2, 12.11.1993, p. 85-88.

Research output: Contribution to journalArticle

Chung, Kyungsoon ; Kim, Hee Jin ; Na, Heung Sik ; Park, Mae Ja ; Chung, Jin Mo. / Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain. In: Neuroscience Letters. 1993 ; Vol. 162, No. 1-2. pp. 85-88.
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