Absence of Bcl10 gene mutations in Ewing's sarcomas

Yong Koo Park, Sung Gil Chi, K. Krishnan Unni

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas. Somatic mutations of Bcl10 were found in not only t(1;14)-bearing MALT lymphomas, but also a wide range of other tumors. To clarify the actual frequency and spectrum of Bcl10 mutations in primary malignant Ewing's sarcomas, we examined 31 cases of Ewing's sarcomas. Polymerase chain reaction single-stranded conformation polymorphism (PCR-SSCP) and sequencing analyses were done. No Bcl10 mutations were found in our series of Ewing's sarcomas. While screening for mutations, we found three polymorphisms at codons 8 exon 1 of the Bcl10 gene. Our results strongly suggest that somatic mutations of Bcl10 are extremely rare in Ewing's sarcomas and do not commonly contribute to their molecular pathogenesis.

Original languageEnglish
Pages (from-to)1333-1335
Number of pages3
JournalOncology reports
Volume8
Issue number6
DOIs
Publication statusPublished - 2001
Externally publishedYes

Keywords

  • Bcl10
  • Ewing's sarcoma
  • Mutation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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