Accuracy and precision analysis of 3-d cancer atlas registration for targeted prostate biopsy via predictive deformation modeling

Ramkrishnan Narayanan, Albaha Barqawi, David Crawford, Katsuto Shinohara, Anne Simoneau, Dinggang Shen, Christos Davatzikos, Jasjit Suri

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

New biopsy plans are being proposed to improve the detection of significant cancers in the prostate. Among these methods are those that suggest new needle sites, more sites, and also optimal orientations for targeted biopsy. The key challenge being the maximization of the detection of cancers while at the same time using small number of needles to reduce risk of patient anxiety, bleeding and incontinence. To address the fairly consistent spatial inhomogeneity of cancers found among individuals within the population, researchers constructed a cancer atlas of the prostate. The atlas displayed voxel-wise likelihood of cancer occurrences within the prostate, and an optimal 6-7 biopsy scheme to maximize cancer detection. To be useful clinically, the atlas must be warped to the patient's transrectal ultrasound image (TRUS). Previously we suggested use of a shape model to register the surface of the atlas to the segmented prostate surface from the TRUS image reducing the degrees of freedom and computation time. This surface correspondence was used to elastically warp the entire atlas volume to register with the subject. Here we discuss a fast predictive approach where elastic volume warps are also used to train the shape model offline resulting in the construction of an extended shape basis. The surface registration of the atlas and the segmented subject surface yields projections on the extended shape basis from which volume warps can be directly inferred. The accuracy and precision of this predictive method was compared with the original method to analyze the speed-accuracy and precision trade off. We found the average accuracy and precision to be less than 1 mm.

Original languageEnglish
Title of host publicationProceedings of the 6th IASTED International Conference on Biomedical Engineering, BioMED 2008
Pages222-226
Number of pages5
Publication statusPublished - 2008 Dec 1
Externally publishedYes
Event6th IASTED International Conference on Biomedical Engineering, BioMED 2008 - Innsbruck, Austria
Duration: 2008 Feb 132008 Feb 15

Other

Other6th IASTED International Conference on Biomedical Engineering, BioMED 2008
CountryAustria
CityInnsbruck
Period08/2/1308/2/15

Fingerprint

Biopsy
Needles
Ultrasonics

Keywords

  • Atlas
  • Biopsy
  • Cancer
  • Prostate
  • Registration
  • Ultrasound

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Narayanan, R., Barqawi, A., Crawford, D., Shinohara, K., Simoneau, A., Shen, D., ... Suri, J. (2008). Accuracy and precision analysis of 3-d cancer atlas registration for targeted prostate biopsy via predictive deformation modeling. In Proceedings of the 6th IASTED International Conference on Biomedical Engineering, BioMED 2008 (pp. 222-226)

Accuracy and precision analysis of 3-d cancer atlas registration for targeted prostate biopsy via predictive deformation modeling. / Narayanan, Ramkrishnan; Barqawi, Albaha; Crawford, David; Shinohara, Katsuto; Simoneau, Anne; Shen, Dinggang; Davatzikos, Christos; Suri, Jasjit.

Proceedings of the 6th IASTED International Conference on Biomedical Engineering, BioMED 2008. 2008. p. 222-226.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Narayanan, R, Barqawi, A, Crawford, D, Shinohara, K, Simoneau, A, Shen, D, Davatzikos, C & Suri, J 2008, Accuracy and precision analysis of 3-d cancer atlas registration for targeted prostate biopsy via predictive deformation modeling. in Proceedings of the 6th IASTED International Conference on Biomedical Engineering, BioMED 2008. pp. 222-226, 6th IASTED International Conference on Biomedical Engineering, BioMED 2008, Innsbruck, Austria, 08/2/13.
Narayanan R, Barqawi A, Crawford D, Shinohara K, Simoneau A, Shen D et al. Accuracy and precision analysis of 3-d cancer atlas registration for targeted prostate biopsy via predictive deformation modeling. In Proceedings of the 6th IASTED International Conference on Biomedical Engineering, BioMED 2008. 2008. p. 222-226
Narayanan, Ramkrishnan ; Barqawi, Albaha ; Crawford, David ; Shinohara, Katsuto ; Simoneau, Anne ; Shen, Dinggang ; Davatzikos, Christos ; Suri, Jasjit. / Accuracy and precision analysis of 3-d cancer atlas registration for targeted prostate biopsy via predictive deformation modeling. Proceedings of the 6th IASTED International Conference on Biomedical Engineering, BioMED 2008. 2008. pp. 222-226
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