Accuracy of lung nodule volumetry in low-dose CT with iterative reconstruction: An anthropomorphic thoracic phantom study

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Abstract

Objective: The purpose of this studywas to assess accuracy of lung nodule volumetry in low-dose CT with application of iterative reconstruction (IR) according to nodule size, nodule density and CT tube currents, using artificial lung nodules within an anthropomorphic thoracic phantom.

Methods: Eight artificial nodules (four diameters: 5, 8, 10 and 12mm; two CT densities: -630HU that represents ground-glass nodule and +100HU that represents solid nodule) were randomly placed inside a thoracic phantom. Scans were performed with tube current-time product to 10, 20, 30 and 50mAs. Images were reconstructed with IR and filtered back projection (FBP). We compared volume estimates to a reference standard and calculated the absolute percentage error (APE).

Results: The APE of all nodules was significantly lower when IR was used than with FBP (7.5± 4.7% compared with 9.0±6.9%; p<0.001). The effect of IR was more pronounced for smaller nodules (p<0.001). IR showed a significantly lower APE than FBP in ground-glass nodules (p<0.0001), and the difference was more pronounced at the lowest tube current (11.8±5.9% compared with 21.3± 6.1%; p<0.0001). The effect of IR was most pronounced for ground-glass nodules in the lowest CT tube current.

Conclusion: Lung nodule volumetry in low-dose CT by application of IR showed reliable accuracy in a phantom study. Lung nodule volumetry can be reliably applicable to all lung nodules including small, ground-glass nodules even in ultra-low-dose CT with application of IR.

Advances in knowledge: IR significantly improved the accuracy of lung nodule volumetry compared with FBP particularly for ground-glass (-630HU) nodules. Volumetry in low-dose CT can be utilized in patient with lung nodule work-up, and IR has benefit for small, groundglass lung nodules in low-dose CT.

Original languageEnglish
Article number20130644
JournalBritish Journal of Radiology
Volume87
Issue number1041
DOIs
Publication statusPublished - 2014 Jan 1

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Thorax
Lung
Glass

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{07d45726d26e4ba08e432e425584a9c4,
title = "Accuracy of lung nodule volumetry in low-dose CT with iterative reconstruction: An anthropomorphic thoracic phantom study",
abstract = "Objective: The purpose of this studywas to assess accuracy of lung nodule volumetry in low-dose CT with application of iterative reconstruction (IR) according to nodule size, nodule density and CT tube currents, using artificial lung nodules within an anthropomorphic thoracic phantom.Methods: Eight artificial nodules (four diameters: 5, 8, 10 and 12mm; two CT densities: -630HU that represents ground-glass nodule and +100HU that represents solid nodule) were randomly placed inside a thoracic phantom. Scans were performed with tube current-time product to 10, 20, 30 and 50mAs. Images were reconstructed with IR and filtered back projection (FBP). We compared volume estimates to a reference standard and calculated the absolute percentage error (APE).Results: The APE of all nodules was significantly lower when IR was used than with FBP (7.5± 4.7{\%} compared with 9.0±6.9{\%}; p<0.001). The effect of IR was more pronounced for smaller nodules (p<0.001). IR showed a significantly lower APE than FBP in ground-glass nodules (p<0.0001), and the difference was more pronounced at the lowest tube current (11.8±5.9{\%} compared with 21.3± 6.1{\%}; p<0.0001). The effect of IR was most pronounced for ground-glass nodules in the lowest CT tube current.Conclusion: Lung nodule volumetry in low-dose CT by application of IR showed reliable accuracy in a phantom study. Lung nodule volumetry can be reliably applicable to all lung nodules including small, ground-glass nodules even in ultra-low-dose CT with application of IR.Advances in knowledge: IR significantly improved the accuracy of lung nodule volumetry compared with FBP particularly for ground-glass (-630HU) nodules. Volumetry in low-dose CT can be utilized in patient with lung nodule work-up, and IR has benefit for small, groundglass lung nodules in low-dose CT.",
author = "Doo, {K. W.} and Eun-Young Kang and Hwan-Seok Yong and Woo, {Ok Hee} and Lee, {Ki Yeol} and Oh, {Yu Whan}",
year = "2014",
month = "1",
day = "1",
doi = "10.1259/bjr.20130644",
language = "English",
volume = "87",
journal = "The British journal of radiology.",
issn = "0007-1285",
publisher = "British Institute of Radiology",
number = "1041",

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T1 - Accuracy of lung nodule volumetry in low-dose CT with iterative reconstruction

T2 - An anthropomorphic thoracic phantom study

AU - Doo, K. W.

AU - Kang, Eun-Young

AU - Yong, Hwan-Seok

AU - Woo, Ok Hee

AU - Lee, Ki Yeol

AU - Oh, Yu Whan

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective: The purpose of this studywas to assess accuracy of lung nodule volumetry in low-dose CT with application of iterative reconstruction (IR) according to nodule size, nodule density and CT tube currents, using artificial lung nodules within an anthropomorphic thoracic phantom.Methods: Eight artificial nodules (four diameters: 5, 8, 10 and 12mm; two CT densities: -630HU that represents ground-glass nodule and +100HU that represents solid nodule) were randomly placed inside a thoracic phantom. Scans were performed with tube current-time product to 10, 20, 30 and 50mAs. Images were reconstructed with IR and filtered back projection (FBP). We compared volume estimates to a reference standard and calculated the absolute percentage error (APE).Results: The APE of all nodules was significantly lower when IR was used than with FBP (7.5± 4.7% compared with 9.0±6.9%; p<0.001). The effect of IR was more pronounced for smaller nodules (p<0.001). IR showed a significantly lower APE than FBP in ground-glass nodules (p<0.0001), and the difference was more pronounced at the lowest tube current (11.8±5.9% compared with 21.3± 6.1%; p<0.0001). The effect of IR was most pronounced for ground-glass nodules in the lowest CT tube current.Conclusion: Lung nodule volumetry in low-dose CT by application of IR showed reliable accuracy in a phantom study. Lung nodule volumetry can be reliably applicable to all lung nodules including small, ground-glass nodules even in ultra-low-dose CT with application of IR.Advances in knowledge: IR significantly improved the accuracy of lung nodule volumetry compared with FBP particularly for ground-glass (-630HU) nodules. Volumetry in low-dose CT can be utilized in patient with lung nodule work-up, and IR has benefit for small, groundglass lung nodules in low-dose CT.

AB - Objective: The purpose of this studywas to assess accuracy of lung nodule volumetry in low-dose CT with application of iterative reconstruction (IR) according to nodule size, nodule density and CT tube currents, using artificial lung nodules within an anthropomorphic thoracic phantom.Methods: Eight artificial nodules (four diameters: 5, 8, 10 and 12mm; two CT densities: -630HU that represents ground-glass nodule and +100HU that represents solid nodule) were randomly placed inside a thoracic phantom. Scans were performed with tube current-time product to 10, 20, 30 and 50mAs. Images were reconstructed with IR and filtered back projection (FBP). We compared volume estimates to a reference standard and calculated the absolute percentage error (APE).Results: The APE of all nodules was significantly lower when IR was used than with FBP (7.5± 4.7% compared with 9.0±6.9%; p<0.001). The effect of IR was more pronounced for smaller nodules (p<0.001). IR showed a significantly lower APE than FBP in ground-glass nodules (p<0.0001), and the difference was more pronounced at the lowest tube current (11.8±5.9% compared with 21.3± 6.1%; p<0.0001). The effect of IR was most pronounced for ground-glass nodules in the lowest CT tube current.Conclusion: Lung nodule volumetry in low-dose CT by application of IR showed reliable accuracy in a phantom study. Lung nodule volumetry can be reliably applicable to all lung nodules including small, ground-glass nodules even in ultra-low-dose CT with application of IR.Advances in knowledge: IR significantly improved the accuracy of lung nodule volumetry compared with FBP particularly for ground-glass (-630HU) nodules. Volumetry in low-dose CT can be utilized in patient with lung nodule work-up, and IR has benefit for small, groundglass lung nodules in low-dose CT.

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