Abstract
Background Performing a restaging work-up with magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG PET/CT) can provide information about the effects that are related to preoperative concurrent chemoradiotherapy (CCRT). The purpose of the present study was to investigate the accuracy of MRI and 18F-FDG PET/CT for restaging after preoperative CCRT for rectal cancer. Methods Between April 2005 and February 2006, 30 patients with histologically proven rectal adenocarcinoma were included in this study. Pelvic MRI and 18F-FDG PET/CT were performed to clinically restage the tumor after CCRT. The results of the pathologic staging were correlated with those of the MRI and 18F-FDG PET/CT after CCRT. Two patients underwent transanal endoscopic microsurgery after CCRT, and they were excluded when the N category was evaluated. Results The overall accuracy of MRI for the T category was 67% (κ = 0.422, P = 0.003), whereas overstaging and understaging occurred in 30 and 3% of the patients, respectively. For the N category, accurate staging was noted in 75% (κ = 0.410, P = 0.030) of all the patients, whereas 14% were overstaged and 11% were understaged. The overall accuracy rates for the T and N categories with performing 18F-FDG PET/CT were 60% (κ = 0.372, P = 0.004) and 71% (κ = 0.097, P = 0.549), respectively. While MRI could not predict any patient who showed a pathologic complete response, 18F-FDG PET/CT predicted three of the four patients who showed a pathologic complete response after preoperative CCRT. Furthermore, 18F-FDG PET/CT identified distant metastases with an accuracy rate of 97%. Conclusions For restaging patients with rectal cancer after preoperative CCRT, MRI is a useful diagnostic modality to predict both the T and N categories. 18F-FDG PET/CT is helpful in predicting a pathologic complete response and in finding metastasis after preoperative CCRT.
| Original language | English |
|---|---|
| Pages (from-to) | 2688-2694 |
| Number of pages | 7 |
| Journal | World Journal of Surgery |
| Volume | 33 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2009 Jan 1 |
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ASJC Scopus subject areas
- Surgery
Cite this
Accuracy of MRI and 18F-FDG PET/CT for restaging after preoperative concurrent chemoradiotherapy for rectal cancer. / Cho, Yong Beom; Chun, Ho Kyung; Kim, Min Ju; Choi, Joon Young; Park, Chi Min; Kim, Byung Tae; Lee, Soon Jin; Yun, Seong Hyeon; Kim, Hee Cheol; Lee, Woo Yong.
In: World Journal of Surgery, Vol. 33, No. 12, 01.01.2009, p. 2688-2694.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Accuracy of MRI and 18F-FDG PET/CT for restaging after preoperative concurrent chemoradiotherapy for rectal cancer
AU - Cho, Yong Beom
AU - Chun, Ho Kyung
AU - Kim, Min Ju
AU - Choi, Joon Young
AU - Park, Chi Min
AU - Kim, Byung Tae
AU - Lee, Soon Jin
AU - Yun, Seong Hyeon
AU - Kim, Hee Cheol
AU - Lee, Woo Yong
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Background Performing a restaging work-up with magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG PET/CT) can provide information about the effects that are related to preoperative concurrent chemoradiotherapy (CCRT). The purpose of the present study was to investigate the accuracy of MRI and 18F-FDG PET/CT for restaging after preoperative CCRT for rectal cancer. Methods Between April 2005 and February 2006, 30 patients with histologically proven rectal adenocarcinoma were included in this study. Pelvic MRI and 18F-FDG PET/CT were performed to clinically restage the tumor after CCRT. The results of the pathologic staging were correlated with those of the MRI and 18F-FDG PET/CT after CCRT. Two patients underwent transanal endoscopic microsurgery after CCRT, and they were excluded when the N category was evaluated. Results The overall accuracy of MRI for the T category was 67% (κ = 0.422, P = 0.003), whereas overstaging and understaging occurred in 30 and 3% of the patients, respectively. For the N category, accurate staging was noted in 75% (κ = 0.410, P = 0.030) of all the patients, whereas 14% were overstaged and 11% were understaged. The overall accuracy rates for the T and N categories with performing 18F-FDG PET/CT were 60% (κ = 0.372, P = 0.004) and 71% (κ = 0.097, P = 0.549), respectively. While MRI could not predict any patient who showed a pathologic complete response, 18F-FDG PET/CT predicted three of the four patients who showed a pathologic complete response after preoperative CCRT. Furthermore, 18F-FDG PET/CT identified distant metastases with an accuracy rate of 97%. Conclusions For restaging patients with rectal cancer after preoperative CCRT, MRI is a useful diagnostic modality to predict both the T and N categories. 18F-FDG PET/CT is helpful in predicting a pathologic complete response and in finding metastasis after preoperative CCRT.
AB - Background Performing a restaging work-up with magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG PET/CT) can provide information about the effects that are related to preoperative concurrent chemoradiotherapy (CCRT). The purpose of the present study was to investigate the accuracy of MRI and 18F-FDG PET/CT for restaging after preoperative CCRT for rectal cancer. Methods Between April 2005 and February 2006, 30 patients with histologically proven rectal adenocarcinoma were included in this study. Pelvic MRI and 18F-FDG PET/CT were performed to clinically restage the tumor after CCRT. The results of the pathologic staging were correlated with those of the MRI and 18F-FDG PET/CT after CCRT. Two patients underwent transanal endoscopic microsurgery after CCRT, and they were excluded when the N category was evaluated. Results The overall accuracy of MRI for the T category was 67% (κ = 0.422, P = 0.003), whereas overstaging and understaging occurred in 30 and 3% of the patients, respectively. For the N category, accurate staging was noted in 75% (κ = 0.410, P = 0.030) of all the patients, whereas 14% were overstaged and 11% were understaged. The overall accuracy rates for the T and N categories with performing 18F-FDG PET/CT were 60% (κ = 0.372, P = 0.004) and 71% (κ = 0.097, P = 0.549), respectively. While MRI could not predict any patient who showed a pathologic complete response, 18F-FDG PET/CT predicted three of the four patients who showed a pathologic complete response after preoperative CCRT. Furthermore, 18F-FDG PET/CT identified distant metastases with an accuracy rate of 97%. Conclusions For restaging patients with rectal cancer after preoperative CCRT, MRI is a useful diagnostic modality to predict both the T and N categories. 18F-FDG PET/CT is helpful in predicting a pathologic complete response and in finding metastasis after preoperative CCRT.
UR - http://www.scopus.com/inward/record.url?scp=77956065029&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956065029&partnerID=8YFLogxK
U2 - 10.1007/S00268-009-0248-3
DO - 10.1007/S00268-009-0248-3
M3 - Article
C2 - 19823904
AN - SCOPUS:77956065029
VL - 33
SP - 2688
EP - 2694
JO - World Journal of Surgery
JF - World Journal of Surgery
SN - 0364-2313
IS - 12
ER -