Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes

Seong Su Hong, Ji Hae Lee, Wonsik Jeong, Nahyun Kim, Hui Zi Jin, Bang Yeon Hwang, Hak Ju Lee, Sung-Joon Lee, Dae Sik Jang, Dongho Lee

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A new acetylenic acid, (10E,14Z)-9-oxooctadeca-10,14-dien-12-ynoic acid (1), was isolated from the edible mushroom Chanterelle (Cantharellus cibarius), together with a known acetylenic acid, (10E,14Z)-9-hydroxyoctadeca-10,14-dien- 12-ynoic acid (2) and their structures were determined through analysis of NMR and mass data. The new acetylenic acid (1) specifically activated peroxisome proliferator-activated receptor (PPAR)-γ with an EC 50 value of 1.88 μM as measured by a reporter gene assay. Expression of PPAR-γ target genes were significantly altered as well, supporting the hypothesis that compound 1 is a PPAR-γ potential agonist that regulates transcription of the PPAR-γ target genes.

Original languageEnglish
Pages (from-to)2347-2349
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number6
DOIs
Publication statusPublished - 2012 Mar 15

Fingerprint

Peroxisome Proliferator-Activated Receptors
PPAR gamma
Agaricales
Gene expression
Genes
Gene Expression
Acids
Transcription
Reporter Genes
Assays
Nuclear magnetic resonance
2-hexadecynoic acid

Keywords

  • Acetylenic acid
  • Cantharellus cibarius
  • Chanterelle
  • Peroxisome proliferator-activated receptor (PPAR)-γ agonist

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes. / Hong, Seong Su; Lee, Ji Hae; Jeong, Wonsik; Kim, Nahyun; Jin, Hui Zi; Hwang, Bang Yeon; Lee, Hak Ju; Lee, Sung-Joon; Jang, Dae Sik; Lee, Dongho.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 22, No. 6, 15.03.2012, p. 2347-2349.

Research output: Contribution to journalArticle

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AU - Hwang, Bang Yeon

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