Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes

Seong Su Hong, Ji Hae Lee, Wonsik Jeong, Nahyun Kim, Hui Zi Jin, Bang Yeon Hwang, Hak Ju Lee, Sung Joon Lee, Dae Sik Jang, Dongho Lee

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

A new acetylenic acid, (10E,14Z)-9-oxooctadeca-10,14-dien-12-ynoic acid (1), was isolated from the edible mushroom Chanterelle (Cantharellus cibarius), together with a known acetylenic acid, (10E,14Z)-9-hydroxyoctadeca-10,14-dien- 12-ynoic acid (2) and their structures were determined through analysis of NMR and mass data. The new acetylenic acid (1) specifically activated peroxisome proliferator-activated receptor (PPAR)-γ with an EC 50 value of 1.88 μM as measured by a reporter gene assay. Expression of PPAR-γ target genes were significantly altered as well, supporting the hypothesis that compound 1 is a PPAR-γ potential agonist that regulates transcription of the PPAR-γ target genes.

Original languageEnglish
Pages (from-to)2347-2349
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number6
DOIs
Publication statusPublished - 2012 Mar 15

Keywords

  • Acetylenic acid
  • Cantharellus cibarius
  • Chanterelle
  • Peroxisome proliferator-activated receptor (PPAR)-γ agonist

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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