Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes

Seong Su Hong; Ji Hae Lee; Wonsik Jeong; Nahyun Kim; Hui Zi Jin; Bang Yeon Hwang; Hak Ju Lee; Sung Joon Lee; Dae Sik Jang; Dongho Lee

doi:10.1016/j.bmcl.2012.01.070

Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes

Seong Su Hong, Ji Hae Lee, Wonsik Jeong, Nahyun Kim, Hui Zi Jin, Bang Yeon Hwang, Hak Ju Lee, Sung Joon Lee, Dae Sik Jang, Dongho Lee

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A new acetylenic acid, (10E,14Z)-9-oxooctadeca-10,14-dien-12-ynoic acid (1), was isolated from the edible mushroom Chanterelle (Cantharellus cibarius), together with a known acetylenic acid, (10E,14Z)-9-hydroxyoctadeca-10,14-dien- 12-ynoic acid (2) and their structures were determined through analysis of NMR and mass data. The new acetylenic acid (1) specifically activated peroxisome proliferator-activated receptor (PPAR)-γ with an EC ₅₀ value of 1.88 μM as measured by a reporter gene assay. Expression of PPAR-γ target genes were significantly altered as well, supporting the hypothesis that compound 1 is a PPAR-γ potential agonist that regulates transcription of the PPAR-γ target genes.

Original language	English
Pages (from-to)	2347-2349
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	6
DOIs	https://doi.org/10.1016/j.bmcl.2012.01.070
Publication status	Published - 2012 Mar 15

Keywords

Acetylenic acid
Cantharellus cibarius
Chanterelle
Peroxisome proliferator-activated receptor (PPAR)-γ agonist

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2012.01.070

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Hong, S. S., Lee, J. H., Jeong, W., Kim, N., Jin, H. Z., Hwang, B. Y., Lee, H. J., Lee, S. J., Jang, D. S., & Lee, D. (2012). Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes. Bioorganic and Medicinal Chemistry Letters, 22(6), 2347-2349. https://doi.org/10.1016/j.bmcl.2012.01.070

Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes. / Hong, Seong Su; Lee, Ji Hae; Jeong, Wonsik et al.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 22, No. 6, 15.03.2012, p. 2347-2349.

Research output: Contribution to journal › Article › peer-review

Hong, SS, Lee, JH, Jeong, W, Kim, N, Jin, HZ, Hwang, BY, Lee, HJ, Lee, SJ, Jang, DS & Lee, D 2012, 'Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes', Bioorganic and Medicinal Chemistry Letters, vol. 22, no. 6, pp. 2347-2349. https://doi.org/10.1016/j.bmcl.2012.01.070

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title = "Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes",

abstract = "A new acetylenic acid, (10E,14Z)-9-oxooctadeca-10,14-dien-12-ynoic acid (1), was isolated from the edible mushroom Chanterelle (Cantharellus cibarius), together with a known acetylenic acid, (10E,14Z)-9-hydroxyoctadeca-10,14-dien- 12-ynoic acid (2) and their structures were determined through analysis of NMR and mass data. The new acetylenic acid (1) specifically activated peroxisome proliferator-activated receptor (PPAR)-γ with an EC 50 value of 1.88 μM as measured by a reporter gene assay. Expression of PPAR-γ target genes were significantly altered as well, supporting the hypothesis that compound 1 is a PPAR-γ potential agonist that regulates transcription of the PPAR-γ target genes.",

keywords = "Acetylenic acid, Cantharellus cibarius, Chanterelle, Peroxisome proliferator-activated receptor (PPAR)-γ agonist",

author = "Hong, {Seong Su} and Lee, {Ji Hae} and Wonsik Jeong and Nahyun Kim and Jin, {Hui Zi} and Hwang, {Bang Yeon} and Lee, {Hak Ju} and Lee, {Sung Joon} and Jang, {Dae Sik} and Dongho Lee",

note = "Funding Information: This study was supported by Forest Science & Technology Project (No. S120910L130140, Korea Forest Service, Republic of Korea) and Agenda Project (No. 20100501030008, Rural Development Administration, Republic of Korea). ",

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doi = "10.1016/j.bmcl.2012.01.070",

language = "English",

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AU - Jeong, Wonsik

AU - Kim, Nahyun

AU - Jin, Hui Zi

AU - Hwang, Bang Yeon

AU - Lee, Hak Ju

AU - Lee, Sung Joon

AU - Jang, Dae Sik

AU - Lee, Dongho

N1 - Funding Information: This study was supported by Forest Science & Technology Project (No. S120910L130140, Korea Forest Service, Republic of Korea) and Agenda Project (No. 20100501030008, Rural Development Administration, Republic of Korea).

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Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes

Abstract

Keywords

ASJC Scopus subject areas

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