Achievement of the National Kidney Foundation Kidney Disease Outcomes Quality initiative

Recommended serum calcium, phosphate and parathyroid hormone values with parathyroidectomy In patients with secondary hyperparathyroidism

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2 Citations (Scopus)

Abstract

Purpose: The National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-K/DOQI) 2003 has established guidelines for the treatment of secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease - minerals and bone disorder (CKD-MBD). This study evaluated parathyroidectomy in SHPT patients for the achievement of the NKF-K/DOQI-recommended values of serum calcium, phosphate, and parathyroid hormone (PTH). Methods: Between January 2005 and December 2010, parathyroidectomy was performed as recommended by the NKF-K/DOQI guidelines in 81 patients with SHPT and CKD-MBD. Serum PTH, calcium, and phosphate levels were measured prior to and 6, 12, 36, and 60 months after parathyroidectomy. Results: Calcium, phosphate, and PTH levels dropped shortly after parathyroidectomy; however, a slight increase showed in the long term. Calcium levels increased for up to 60 months. Phosphate and PTH levels increased for up to 36 months but tended to decrease slightly at 60 months. The mean values were within the target ranges, except for PTH at 36 months. The target parameters of serum phosphate (42.9-61.1% of patients) and serum calcium (a peak of 61.1% of patients at 36 months, but only 28.6% at 60 months) were achieved the most. Less than 34% of patients achieved the recommended range for PTH. Conclusion: Parathyroidectomy was not an optimal procedure for achieving all the biochemical parameters recommended by the NKF-K/DOQI. Although it was helpful in attaining the recommended values for serum calcium and phosphate in SHPT patients resistant to medical therapy, the PTH levels did not fall within the recommended range.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalJournal of the Korean Surgical Society
Volume85
Issue number1
DOIs
Publication statusPublished - 2013 Jul 1

Fingerprint

Parathyroidectomy
Secondary Hyperparathyroidism
Kidney Diseases
Parathyroid Hormone
Kidney
Serum
Chronic Kidney Disease-Mineral and Bone Disorder
Phosphates
Guidelines
Calcium
calcium phosphate
Therapeutics

Keywords

  • Calcium
  • Parathyroid hormone
  • Parathyroidectomy
  • Phosphates

ASJC Scopus subject areas

  • Surgery

Cite this

@article{ecfc9e9658e14c1cb6ec45c6aefed0ba,
title = "Achievement of the National Kidney Foundation Kidney Disease Outcomes Quality initiative: Recommended serum calcium, phosphate and parathyroid hormone values with parathyroidectomy In patients with secondary hyperparathyroidism",
abstract = "Purpose: The National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-K/DOQI) 2003 has established guidelines for the treatment of secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease - minerals and bone disorder (CKD-MBD). This study evaluated parathyroidectomy in SHPT patients for the achievement of the NKF-K/DOQI-recommended values of serum calcium, phosphate, and parathyroid hormone (PTH). Methods: Between January 2005 and December 2010, parathyroidectomy was performed as recommended by the NKF-K/DOQI guidelines in 81 patients with SHPT and CKD-MBD. Serum PTH, calcium, and phosphate levels were measured prior to and 6, 12, 36, and 60 months after parathyroidectomy. Results: Calcium, phosphate, and PTH levels dropped shortly after parathyroidectomy; however, a slight increase showed in the long term. Calcium levels increased for up to 60 months. Phosphate and PTH levels increased for up to 36 months but tended to decrease slightly at 60 months. The mean values were within the target ranges, except for PTH at 36 months. The target parameters of serum phosphate (42.9-61.1{\%} of patients) and serum calcium (a peak of 61.1{\%} of patients at 36 months, but only 28.6{\%} at 60 months) were achieved the most. Less than 34{\%} of patients achieved the recommended range for PTH. Conclusion: Parathyroidectomy was not an optimal procedure for achieving all the biochemical parameters recommended by the NKF-K/DOQI. Although it was helpful in attaining the recommended values for serum calcium and phosphate in SHPT patients resistant to medical therapy, the PTH levels did not fall within the recommended range.",
keywords = "Calcium, Parathyroid hormone, Parathyroidectomy, Phosphates",
author = "Kim, {Woo Young} and Lee, {Jae Bok} and Kim, {Hoon Yub} and Woo, {Sang- Uk} and Son, {Gil Soo} and Bae, {Jeoung Won}",
year = "2013",
month = "7",
day = "1",
doi = "10.4174/jkss.2013.85.1.25",
language = "English",
volume = "85",
pages = "25--29",
journal = "Annals of Surgical Treatment and Research",
issn = "2288-6575",
publisher = "Korean Surgical Society",
number = "1",

}

TY - JOUR

T1 - Achievement of the National Kidney Foundation Kidney Disease Outcomes Quality initiative

T2 - Recommended serum calcium, phosphate and parathyroid hormone values with parathyroidectomy In patients with secondary hyperparathyroidism

AU - Kim, Woo Young

AU - Lee, Jae Bok

AU - Kim, Hoon Yub

AU - Woo, Sang- Uk

AU - Son, Gil Soo

AU - Bae, Jeoung Won

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Purpose: The National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-K/DOQI) 2003 has established guidelines for the treatment of secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease - minerals and bone disorder (CKD-MBD). This study evaluated parathyroidectomy in SHPT patients for the achievement of the NKF-K/DOQI-recommended values of serum calcium, phosphate, and parathyroid hormone (PTH). Methods: Between January 2005 and December 2010, parathyroidectomy was performed as recommended by the NKF-K/DOQI guidelines in 81 patients with SHPT and CKD-MBD. Serum PTH, calcium, and phosphate levels were measured prior to and 6, 12, 36, and 60 months after parathyroidectomy. Results: Calcium, phosphate, and PTH levels dropped shortly after parathyroidectomy; however, a slight increase showed in the long term. Calcium levels increased for up to 60 months. Phosphate and PTH levels increased for up to 36 months but tended to decrease slightly at 60 months. The mean values were within the target ranges, except for PTH at 36 months. The target parameters of serum phosphate (42.9-61.1% of patients) and serum calcium (a peak of 61.1% of patients at 36 months, but only 28.6% at 60 months) were achieved the most. Less than 34% of patients achieved the recommended range for PTH. Conclusion: Parathyroidectomy was not an optimal procedure for achieving all the biochemical parameters recommended by the NKF-K/DOQI. Although it was helpful in attaining the recommended values for serum calcium and phosphate in SHPT patients resistant to medical therapy, the PTH levels did not fall within the recommended range.

AB - Purpose: The National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-K/DOQI) 2003 has established guidelines for the treatment of secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease - minerals and bone disorder (CKD-MBD). This study evaluated parathyroidectomy in SHPT patients for the achievement of the NKF-K/DOQI-recommended values of serum calcium, phosphate, and parathyroid hormone (PTH). Methods: Between January 2005 and December 2010, parathyroidectomy was performed as recommended by the NKF-K/DOQI guidelines in 81 patients with SHPT and CKD-MBD. Serum PTH, calcium, and phosphate levels were measured prior to and 6, 12, 36, and 60 months after parathyroidectomy. Results: Calcium, phosphate, and PTH levels dropped shortly after parathyroidectomy; however, a slight increase showed in the long term. Calcium levels increased for up to 60 months. Phosphate and PTH levels increased for up to 36 months but tended to decrease slightly at 60 months. The mean values were within the target ranges, except for PTH at 36 months. The target parameters of serum phosphate (42.9-61.1% of patients) and serum calcium (a peak of 61.1% of patients at 36 months, but only 28.6% at 60 months) were achieved the most. Less than 34% of patients achieved the recommended range for PTH. Conclusion: Parathyroidectomy was not an optimal procedure for achieving all the biochemical parameters recommended by the NKF-K/DOQI. Although it was helpful in attaining the recommended values for serum calcium and phosphate in SHPT patients resistant to medical therapy, the PTH levels did not fall within the recommended range.

KW - Calcium

KW - Parathyroid hormone

KW - Parathyroidectomy

KW - Phosphates

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U2 - 10.4174/jkss.2013.85.1.25

DO - 10.4174/jkss.2013.85.1.25

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VL - 85

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JF - Annals of Surgical Treatment and Research

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