Acid-triggered release of doxorubicin from a hydrazone-linked Gd3+-texaphyrin conjugate

Min Hee Lee, Eun Joong Kim, Hyunseung Lee, Sun Young Park, Kwan Soo Hong, Jong Seung Kim, Jonathan L. Sessler

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The hydrazone-based Gd3+-texaphyrin doxorubicin conjugate 1, releases active doxorubicin at acidic pH values, allowing its components to be followed by two complementary imaging methods, namely Off-On fluorescence enhancement and MR imaging. It thus acts as a promising theranostic agent.

Original languageEnglish
Pages (from-to)10551-10554
Number of pages4
JournalChemical Communications
Volume52
Issue number69
DOIs
Publication statusPublished - 2016

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Lee, M. H., Kim, E. J., Lee, H., Park, S. Y., Hong, K. S., Kim, J. S., & Sessler, J. L. (2016). Acid-triggered release of doxorubicin from a hydrazone-linked Gd3+-texaphyrin conjugate. Chemical Communications, 52(69), 10551-10554. https://doi.org/10.1039/c6cc05673c