Acoustic device for selective platelet extraction from whole blood

Jeonghun Nam, Hyunjung Lim, Dookon Kim, Sehyun Shin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Platelet separation from blood is fundamental technique for biochemical analyses. In this article, we proposed a method to collect platelets from whole blood utilizing standing surface acoustic waves (SSAWs) in a microfluidic device. A polydimethylsiloxane (PDMS) microfluidic device was integrated with interdigitated transducers (IDTs) on a piezoelectric substrate. Whole blood sample was hydrodynamically focused by sheath flow from side inlets. Pressure nodes were designed to locate at side walls, thereby collecting platelets with minimum shear effect. Finally, the RBC clearance ratio from whole blood was found to be 99% and the purity of platelets was close to 98%.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages1326-1328
Number of pages3
Publication statusPublished - 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2011 Oct 22011 Oct 6

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume2

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period11/10/211/10/6

Keywords

  • Microfluidics
  • Platelets
  • Separation
  • Standing surface acoustic wave

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Nam, J., Lim, H., Kim, D., & Shin, S. (2011). Acoustic device for selective platelet extraction from whole blood. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 1326-1328). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 2).