Acoustic effects of lamotrigine in pediatric patients with epilepsy

Minseon Yun; Yoon Mi Choi; So Hee Eun; In Joon Seol; Sun Jun Kim

doi:10.1016/j.braindev.2010.07.007

Acoustic effects of lamotrigine in pediatric patients with epilepsy

Minseon Yun, Yoon Mi Choi, So Hee Eun, In Joon Seol, Sun Jun Kim

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The aim of this study was to investigate the acoustic effects of lamotrigine in pediatric epileptic patients. Newly diagnosed 52 pediatric epileptic patients were assessed standard speech test through a Computerized Speech Lab applied before the beginning of therapy with lamotrigine and 2months after dosage had been stabilized. The voice onset times for /t/, /k^h/, /p′/ and /t′/ after the therapy and those for /p/, /k/, /p^h/, /t^h/ and /k′/ was not affected. Total durations for all stop consonants did not change significantly except that lenis /p/ and /k/ increased significantly (P<0.05). No noteworthy alteration was observed for mean pitch and speaking rate of counting 1-10. Vowel formants and precise articulation rate remained the same. In conclusion, no significant effects of lamotrigine on speech were found in this study. Lamotrigine is safe for acoustic function in pediatric patients.

Original language	English
Pages (from-to)	374-378
Number of pages	5
Journal	Brain and Development
Volume	33
Issue number	5
DOIs	https://doi.org/10.1016/j.braindev.2010.07.007
Publication status	Published - 2011 May

Keywords

Acoustic variation
Epilepsy
Lamotrigine

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental Neuroscience
Clinical Neurology

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title = "Acoustic effects of lamotrigine in pediatric patients with epilepsy",

abstract = "The aim of this study was to investigate the acoustic effects of lamotrigine in pediatric epileptic patients. Newly diagnosed 52 pediatric epileptic patients were assessed standard speech test through a Computerized Speech Lab applied before the beginning of therapy with lamotrigine and 2months after dosage had been stabilized. The voice onset times for /t/, /kh/, /p′/ and /t′/ after the therapy and those for /p/, /k/, /ph/, /th/ and /k′/ was not affected. Total durations for all stop consonants did not change significantly except that lenis /p/ and /k/ increased significantly (P<0.05). No noteworthy alteration was observed for mean pitch and speaking rate of counting 1-10. Vowel formants and precise articulation rate remained the same. In conclusion, no significant effects of lamotrigine on speech were found in this study. Lamotrigine is safe for acoustic function in pediatric patients.",

keywords = "Acoustic variation, Epilepsy, Lamotrigine",

author = "Minseon Yun and Choi, {Yoon Mi} and Eun, {So Hee} and Seol, {In Joon} and Kim, {Sun Jun}",

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T1 - Acoustic effects of lamotrigine in pediatric patients with epilepsy

AU - Yun, Minseon

AU - Choi, Yoon Mi

AU - Eun, So Hee

AU - Seol, In Joon

AU - Kim, Sun Jun

PY - 2011/5

Y1 - 2011/5

N2 - The aim of this study was to investigate the acoustic effects of lamotrigine in pediatric epileptic patients. Newly diagnosed 52 pediatric epileptic patients were assessed standard speech test through a Computerized Speech Lab applied before the beginning of therapy with lamotrigine and 2months after dosage had been stabilized. The voice onset times for /t/, /kh/, /p′/ and /t′/ after the therapy and those for /p/, /k/, /ph/, /th/ and /k′/ was not affected. Total durations for all stop consonants did not change significantly except that lenis /p/ and /k/ increased significantly (P<0.05). No noteworthy alteration was observed for mean pitch and speaking rate of counting 1-10. Vowel formants and precise articulation rate remained the same. In conclusion, no significant effects of lamotrigine on speech were found in this study. Lamotrigine is safe for acoustic function in pediatric patients.

AB - The aim of this study was to investigate the acoustic effects of lamotrigine in pediatric epileptic patients. Newly diagnosed 52 pediatric epileptic patients were assessed standard speech test through a Computerized Speech Lab applied before the beginning of therapy with lamotrigine and 2months after dosage had been stabilized. The voice onset times for /t/, /kh/, /p′/ and /t′/ after the therapy and those for /p/, /k/, /ph/, /th/ and /k′/ was not affected. Total durations for all stop consonants did not change significantly except that lenis /p/ and /k/ increased significantly (P<0.05). No noteworthy alteration was observed for mean pitch and speaking rate of counting 1-10. Vowel formants and precise articulation rate remained the same. In conclusion, no significant effects of lamotrigine on speech were found in this study. Lamotrigine is safe for acoustic function in pediatric patients.

KW - Acoustic variation

KW - Epilepsy

KW - Lamotrigine

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Acoustic effects of lamotrigine in pediatric patients with epilepsy

Abstract

Keywords

ASJC Scopus subject areas

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