Acoustic effects of lamotrigine in pediatric patients with epilepsy

Minseon Yun, Yoon Mi Choi, So Hee Eun, In Joon Seol, Sun Jun Kim

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The aim of this study was to investigate the acoustic effects of lamotrigine in pediatric epileptic patients. Newly diagnosed 52 pediatric epileptic patients were assessed standard speech test through a Computerized Speech Lab applied before the beginning of therapy with lamotrigine and 2months after dosage had been stabilized. The voice onset times for /t/, /kh/, /p′/ and /t′/ after the therapy and those for /p/, /k/, /ph/, /th/ and /k′/ was not affected. Total durations for all stop consonants did not change significantly except that lenis /p/ and /k/ increased significantly (P<0.05). No noteworthy alteration was observed for mean pitch and speaking rate of counting 1-10. Vowel formants and precise articulation rate remained the same. In conclusion, no significant effects of lamotrigine on speech were found in this study. Lamotrigine is safe for acoustic function in pediatric patients.

Original languageEnglish
Pages (from-to)374-378
Number of pages5
JournalBrain and Development
Issue number5
Publication statusPublished - 2011 May
Externally publishedYes


  • Acoustic variation
  • Epilepsy
  • Lamotrigine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology


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