Activatable imaging probes with amplified fluorescent signals

Seulki Lee, Kyeongsoon Park, Kwang Meyung Kim, Kuiwon Choi, Ick Chan Kwon

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Current optical imaging probe applications are hampered by poor sensitivity and specificity to the target, but molecular-level fluorescent signal activation strategies can efficiently overcome these limitations. Recent interdisciplinary research that couples the imaging sciences to fluorophore, peptide, polymer, and inorganic-based chemistry has generated novel imaging probes that exhibit high sensitivity and low background noise in both in vitro and in vivo applications. This feature article introduces and discusses the various approaches described by the term "fluorescent signal activation methods" with respect to their unique imaging probe design strategies and applications.

Original languageEnglish
Pages (from-to)4250-4260
Number of pages11
JournalChemical Communications
Issue number36
DOIs
Publication statusPublished - 2008 Oct 1
Externally publishedYes

Fingerprint

Inorganic Chemistry
Optical Imaging
Noise
Polymers
Imaging techniques
Sensitivity and Specificity
Peptides
Research
Chemical activation
Fluorophores
In Vitro Techniques

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Activatable imaging probes with amplified fluorescent signals. / Lee, Seulki; Park, Kyeongsoon; Kim, Kwang Meyung; Choi, Kuiwon; Kwon, Ick Chan.

In: Chemical Communications, No. 36, 01.10.2008, p. 4250-4260.

Research output: Contribution to journalArticle

Lee, Seulki ; Park, Kyeongsoon ; Kim, Kwang Meyung ; Choi, Kuiwon ; Kwon, Ick Chan. / Activatable imaging probes with amplified fluorescent signals. In: Chemical Communications. 2008 ; No. 36. pp. 4250-4260.
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