Activatable NIRF/MRI dual imaging probe using bio-inspired coating of glycol chitosan on superparamagnetic iron oxide nanoparticles

In Jae Chung, Seong Ik Jeon, Eui Joon Cha, Youngro Byun, Ick Chan Kwon, Young Il Kim, Kwangmeyung Kim, Cheol Hee Ahn

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

MRI and NIRF multimodal imaging probe was fabricated and investigated. Glycol chitosan coated SPION was decorated by MMP-2 substrate conjugating BHQ-3 and Cy5.5 dye at each end (BCMG-SPION). NIRF signals were recovered in the presence of MMP-2 at a sub-nanomolar level. BCMG-SPION produced the maximum NIRF intensity at 48 h post injection in vivo. Evaluation of the BCMG-SPION in the tumor tissue by MRI showed that relative contrast enhancement was 34% higher than normal muscles. NIRF images of excised organs showed the highest NIRF signal in tumor and the intensity was at least 8 times higher than other organs.

Original languageEnglish
Pages (from-to)403-409
Number of pages7
JournalJournal of Industrial and Engineering Chemistry
Volume76
DOIs
Publication statusPublished - 2019 Aug 25
Externally publishedYes

Keywords

  • Bio-inspired adhesion
  • In vivo dual imaging
  • Iron oxide
  • MRI
  • Nanoparticles
  • Optical imaging

ASJC Scopus subject areas

  • Chemical Engineering(all)

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