Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene

Dipanjan Chanda, Yong Hoon Kim, Don Kyu Kim, Min Woo Lee, Su Yeon Lee, Tae Sik Park, Seung Hoi Koo, Chul Ho Lee, Hueng Sik Choi

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Background: The role of Cb1r signaling-mediated activation of Crebh in regulating lipid metabolism and insulin signaling is currently unknown. Results: Cb1r signaling regulates Lipin1 gene transcription via Crebh and inhibits insulin receptor signaling. Conclusion: Crebh-mediated activation of Lipin1 by Cb1r deregulates insulin receptor signaling. Significance: Relieving higher hepatic DAG levels by targeting its upstream regulators might be beneficial to restore insulin signaling.

Original languageEnglish
Pages (from-to)38041-38049
Number of pages9
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
Publication statusPublished - 2012 Nov 2

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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