Activation of macrophages and the intestinal immune system by an orally administered decoction from cultured mycelia of Cordyceps sinensis

Jong Ho Koh, Kwang Won Yu, Hyung Joo Suh, Yang Moon Choi, Tae Seok Ahn

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The effects of an orally administered hot-water extract (HW) from cultured mycelia of Cordyceps sinensis on the activation of macrophages and the intestinal immune system were studied in mice. The general composition of HW was 83.9% carbohydrate, 11.8% protein, 1.9% lipid and 2.4% ash, and the carbohydrates were mainly composed of glucose, mannose, galactose and arabinose (molar ratio of 1.0:0.8:0.5:0.1). HW stimulated the activation (1.7-fold of the saline control) of macrophages and IL-6 production (1.5-fold) at 2.0 g/kg/day. Analyzing the culture supernatant of Peyer's patch cells from C3H/HeJ mice that had been fed with HW at 1.0 g/kg/day for 7 days indicated that the bone marrow cells had significantly proliferated (1.9-fold). In addition, the amounts of GM-CSF and IL-6 in the culture supernatant of Peyer's patch cells at the same dose were significantly increased (1.8-fold and 2.2-fold, respectively). These results indicate that an oral administration of HW may modulate IL-6 production by the activation of macrophages, and also enhance the secretion of hematopoietic growth factors such as GM-CSF and IL-6 from Peyer's patch cells. Since such cytokines as GM-CSF and IL-6 from Peyer's patch cells act on the systemic immune system, it can be assumed that orally administered HW modulated not only the local but also systemic immune system.

Original languageEnglish
Pages (from-to)407-411
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume66
Issue number2
Publication statusPublished - 2002 Feb 1

Fingerprint

Cordyceps
Ophiocordyceps sinensis
macrophage activation
Macrophage Activation
Macrophages
Immune system
Mycelium
mycelium
immune system
Immune System
Peyer's Patches
Peyer's patches
interleukin-6
Chemical activation
Interleukin-6
Water
extracts
Granulocyte-Macrophage Colony-Stimulating Factor
water
Carbohydrates

Keywords

  • Cordyceps sinensis
  • Intestinal immune system
  • Macrophage
  • Peyer's patch

ASJC Scopus subject areas

  • Food Science
  • Applied Microbiology and Biotechnology
  • Chemistry (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Bioengineering

Cite this

Activation of macrophages and the intestinal immune system by an orally administered decoction from cultured mycelia of Cordyceps sinensis. / Koh, Jong Ho; Yu, Kwang Won; Suh, Hyung Joo; Choi, Yang Moon; Ahn, Tae Seok.

In: Bioscience, Biotechnology and Biochemistry, Vol. 66, No. 2, 01.02.2002, p. 407-411.

Research output: Contribution to journalArticle

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