Activation of the leukotriene B4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer cells

Jin Wook Lee, Jae Hong Kim

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Despite the critical role of anoikis resistance in prostate cancer progression, the molecular mechanism causing anoikis resistance remains unclear. Results: BLT2 protects prostate cancer cells against anoikis via a NOX-ROS-NF-B-linked pathway. Conclusion: Activation of the BLT2-linked pathway following cell detachment confers anoikis resistance. Significance: Our findings suggest BLT2 as a key regulator of anoikis resistance in prostate cancer cells.

Original languageEnglish
Pages (from-to)30054-30063
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number42
DOIs
Publication statusPublished - 2013 Oct 18

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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