Abstract
This paper presents a new sealing method for soft polymer (elastomer) microchips. A robust and reversible sealing method, which allows various materials to be bonded and sealed tightly with each other even in aqueous solutions, is developed. A poly (dimethylsiloxane) (PDMS) microchip system, which can actively generate bonding and sealing forces by itself, is invented. By inducing negative pressure into additional closed areas, an instant sucking disk is made. This disk is used to tighten up the conformal contact of soft polymers. Other functionalities of active sealing such as making reusable microchips, patterning cells, and performing cellular assays in a single dish have also been examined and will be discussed hereunder. This technique gives a robust and universal solution for microchip sealing issues by sealing soft polymers with diverse materials in various conditions. Active sealing will simplify numerous assays in lab-on-a-chip industry and will open a new era for cellular microchip assays.
| Original language | English |
|---|---|
| Title of host publication | 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings |
| Pages | 405-408 |
| Number of pages | 4 |
| Volume | 3 |
| Publication status | Published - 2006 Dec 8 |
| Externally published | Yes |
| Event | 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States Duration: 2006 May 7 → 2006 May 11 |
Other
| Other | 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings |
|---|---|
| Country | United States |
| City | Boston, MA |
| Period | 06/5/7 → 06/5/11 |
Fingerprint
Keywords
- Active sealing
- Cell patterning
- Cytotoxicity test
- Reversible sealing
- Soft polymer
ASJC Scopus subject areas
- Engineering(all)
Cite this
Active sealing for soft polymer microchips. / Bang, Hyunwoo; Lee, Won Gu; Park, Junha; Yun, Hoyoung; Lee, Joonmo; Chung, Seok; Cho, Keunchang; Chung, Chanil; Han, Dong Chul; Chang, Jun Keun.
2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings. Vol. 3 2006. p. 405-408.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Active sealing for soft polymer microchips
AU - Bang, Hyunwoo
AU - Lee, Won Gu
AU - Park, Junha
AU - Yun, Hoyoung
AU - Lee, Joonmo
AU - Chung, Seok
AU - Cho, Keunchang
AU - Chung, Chanil
AU - Han, Dong Chul
AU - Chang, Jun Keun
PY - 2006/12/8
Y1 - 2006/12/8
N2 - This paper presents a new sealing method for soft polymer (elastomer) microchips. A robust and reversible sealing method, which allows various materials to be bonded and sealed tightly with each other even in aqueous solutions, is developed. A poly (dimethylsiloxane) (PDMS) microchip system, which can actively generate bonding and sealing forces by itself, is invented. By inducing negative pressure into additional closed areas, an instant sucking disk is made. This disk is used to tighten up the conformal contact of soft polymers. Other functionalities of active sealing such as making reusable microchips, patterning cells, and performing cellular assays in a single dish have also been examined and will be discussed hereunder. This technique gives a robust and universal solution for microchip sealing issues by sealing soft polymers with diverse materials in various conditions. Active sealing will simplify numerous assays in lab-on-a-chip industry and will open a new era for cellular microchip assays.
AB - This paper presents a new sealing method for soft polymer (elastomer) microchips. A robust and reversible sealing method, which allows various materials to be bonded and sealed tightly with each other even in aqueous solutions, is developed. A poly (dimethylsiloxane) (PDMS) microchip system, which can actively generate bonding and sealing forces by itself, is invented. By inducing negative pressure into additional closed areas, an instant sucking disk is made. This disk is used to tighten up the conformal contact of soft polymers. Other functionalities of active sealing such as making reusable microchips, patterning cells, and performing cellular assays in a single dish have also been examined and will be discussed hereunder. This technique gives a robust and universal solution for microchip sealing issues by sealing soft polymers with diverse materials in various conditions. Active sealing will simplify numerous assays in lab-on-a-chip industry and will open a new era for cellular microchip assays.
KW - Active sealing
KW - Cell patterning
KW - Cytotoxicity test
KW - Reversible sealing
KW - Soft polymer
UR - http://www.scopus.com/inward/record.url?scp=33845217354&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845217354&partnerID=8YFLogxK
M3 - Conference contribution
VL - 3
SP - 405
EP - 408
BT - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
ER -