Active sealing for soft polymer microchips

Hyunwoo Bang, Won Gu Lee, Junha Park, Hoyoung Yun, Joonmo Lee, Seok Chung, Keunchang Cho, Chanil Chung, Dong Chul Han, Jun Keun Chang

Research output: Contribution to conferencePaperpeer-review

Abstract

This paper presents a new sealing method for soft polymer (elastomer) microchips. A robust and reversible sealing method, which allows various materials to be bonded and sealed tightly with each other even in aqueous solutions, is developed. A poly (dimethylsiloxane) (PDMS) microchip system, which can actively generate bonding and sealing forces by itself, is invented. By inducing negative pressure into additional closed areas, an instant sucking disk is made. This disk is used to tighten up the conformal contact of soft polymers. Other functionalities of active sealing such as making reusable microchips, patterning cells, and performing cellular assays in a single dish have also been examined and will be discussed hereunder. This technique gives a robust and universal solution for microchip sealing issues by sealing soft polymers with diverse materials in various conditions. Active sealing will simplify numerous assays in lab-on-a-chip industry and will open a new era for cellular microchip assays.

Original languageEnglish
Pages405-408
Number of pages4
Publication statusPublished - 2006
Externally publishedYes
Event2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States
Duration: 2006 May 72006 May 11

Other

Other2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
CountryUnited States
CityBoston, MA
Period06/5/706/5/11

Keywords

  • Active sealing
  • Cell patterning
  • Cytotoxicity test
  • Reversible sealing
  • Soft polymer

ASJC Scopus subject areas

  • Engineering(all)

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